{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(28)"],"submitter":["Gong L"],"pubmed_abstract":["Yindanxinnaotong capsule (YDXNT), a traditional Chinese formula, has been used to treat cardio-cerebrovascular diseases for several decades. Previous research has focused on evaluating the pharmacological properties and main compounds of YDXNT <i>in vitro</i> and <i>in vivo</i>. However, the multiple bioactive compounds <i>in vivo</i> remain poorly understood. In the present research, an integrative strategy using UPLC-Q-TOF-MS combined with UPLC-QqQ-MS was employed to detect the absorbed constituents and investigate the pharmacokinetics of main compounds in the plasma after oral administration of YDXNT. UPLC-Q-TOF-MS was developed to detect the absorbed constituents and their metabolites in the plasma after oral administration in rats. A total of 52 constituents, including 44 prototype co"],"journal":["RSC advances"],"pagination":["15725-15739"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9080097"],"repository":["biostudies-literature"],"pubmed_title":["Identification of absorbed constituents and evaluation of the pharmacokinetics of main compounds after oral administration of yindanxinnaotong by UPLC-Q-TOF-MS and UPLC-QqQ-MS."],"pmcid":["PMC9080097"],"pubmed_authors":["Yang H","Yin X","Fan M","Ma X","Cheng L","Gong L","Xu H","Yuan H","Wang L","Liang R"],"additional_accession":[]},"is_claimable":false,"name":"Identification of absorbed constituents and evaluation of the pharmacokinetics of main compounds after oral administration of yindanxinnaotong by UPLC-Q-TOF-MS and UPLC-QqQ-MS.","description":"Yindanxinnaotong capsule (YDXNT), a traditional Chinese formula, has been used to treat cardio-cerebrovascular diseases for several decades. Previous research has focused on evaluating the pharmacological properties and main compounds of YDXNT <i>in vitro</i> and <i>in vivo</i>. However, the multiple bioactive compounds <i>in vivo</i> remain poorly understood. In the present research, an integrative strategy using UPLC-Q-TOF-MS combined with UPLC-QqQ-MS was employed to detect the absorbed constituents and investigate the pharmacokinetics of main compounds in the plasma after oral administration of YDXNT. UPLC-Q-TOF-MS was developed to detect the absorbed constituents and their metabolites in the plasma after oral administration in rats. A total of 52 constituents, including 44 prototype co","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Apr","modification":"2025-04-26T15:23:44.049Z","creation":"2025-02-19T03:24:45.574Z"},"accession":"S-EPMC9080097","cross_references":{"pubmed":["35539456"],"doi":["10.1039/c7ra12659j"]}}