biostudies-literatureTang XNational Natural Science Foundation of China16410-16418https://www.ebi.ac.uk/biostudies/studies/S-EPMC9080322biostudies-literatureUnknown8(30)Magnetic-hyperthermia-ablation is considered as an effective and minimally invasive technology for tumor therapy. However, inappropriate temperature control could induce an excessively high temperature which brings potential safety problems and limits clinical transformation of this technique. Herein, aiming to control the temperature during magnetic hyperthermia ablation, we develop an intermittent time-set technique for temperature control in magnetic hyperthermia ablation of tumors using a polylactic-<i>co</i>-glycolic acid (PLGA)-Fe₃O₄ implant. <i>In vitro</i>, the intermittent time is set as follows: tubes are continuously heated for 110 seconds. Then the heating process is paused for 20 seconds, and then the tubes are reheated for 10 seconds, followed by repeatiRSC advancesIntermittent time-set technique controlling the temperature of magnetic-hyperthermia-ablation for tumor therapy.PMC9080322812278018163004781601506Yao LZheng YJiang LLing YChen JYing TWang FHu BWang LRan HWang YWang ZTang XXu YfalseIntermittent time-set technique controlling the temperature of magnetic-hyperthermia-ablation for tumor therapy.Magnetic-hyperthermia-ablation is considered as an effective and minimally invasive technology for tumor therapy. However, inappropriate temperature control could induce an excessively high temperature which brings potential safety problems and limits clinical transformation of this technique. Herein, aiming to control the temperature during magnetic hyperthermia ablation, we develop an intermittent time-set technique for temperature control in magnetic hyperthermia ablation of tumors using a polylactic-<i>co</i>-glycolic acid (PLGA)-Fe₃O₄ implant. <i>In vitro</i>, the intermittent time is set as follows: tubes are continuously heated for 110 seconds. Then the heating process is paused for 20 seconds, and then the tubes are reheated for 10 seconds, followed by repeati2018-01-01T00:00:00Z2018 May2025-04-26T04:36:19.095Z2025-04-06T11:11:43.751ZS-EPMC90803223554053410.1039/c8ra01176a