biostudies-literatureLim FPLMinistry of Higher Education, Malaysia21495-21504https://www.ebi.ac.uk/biostudies/studies/S-EPMC9080918biostudies-literatureUnknown8(38)A highly selective, one-pot, three-component synthesis of novel 2-alkyl-substituted 4-aminoimidazo[1,2-<i>a</i>][1,3,5]triazines has been developed. The scope of the method was explored in two dimensions, varying the structures of trialkyl orthoesters and 2-aminoimidazoles in their reactions with cyanamide. Conveniently performed under microwave irradiation, this method was also proved to be efficient under conventional heating. A library of 24 novel compounds was prepared in high purity using this multicomponent approach. Molecular and crystal structures of representative molecules were studied using X-ray crystallography.RSC advancesA one-pot, multicomponent reaction for the synthesis of novel 2-alkyl substituted 4-aminoimidazo[1,2-<i>a</i>][1,3,5]triazines.PMC9080918FRGS/1/2015/SG01/MUSM/03/1Lim FPLDolzhenko AVTan LYTiekink ERTfalseA one-pot, multicomponent reaction for the synthesis of novel 2-alkyl substituted 4-aminoimidazo[1,2-<i>a</i>][1,3,5]triazines.A highly selective, one-pot, three-component synthesis of novel 2-alkyl-substituted 4-aminoimidazo[1,2-<i>a</i>][1,3,5]triazines has been developed. The scope of the method was explored in two dimensions, varying the structures of trialkyl orthoesters and 2-aminoimidazoles in their reactions with cyanamide. Conveniently performed under microwave irradiation, this method was also proved to be efficient under conventional heating. A library of 24 novel compounds was prepared in high purity using this multicomponent approach. Molecular and crystal structures of representative molecules were studied using X-ray crystallography.2018-01-01T00:00:00Z2018 Jun2025-05-18T13:22:56.067Z2025-02-19T04:21:54.089ZS-EPMC90809183553991510.1039/c8ra03703e