{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["39(1)"],"submitter":["Iwase A"],"pubmed_abstract":["4-Phenylbutyric acid (4PBA) is utilized as a drug to treat urea cycle disorders and is also being studied as a potential anticancer drug that acts via its histone deacetylase (HDAC) inhibitor activity. During a search to find small molecules that affect plant regeneration in Arabidopsis, we found that 4PBA treatment promotes this process by mimicking the effect of exogenous auxin. Specifically, plant tissue culture experiments revealed that a medium containing 4PBA enhances callus formation and subsequent shoot regeneration. Analyses with auxin-responsive or cytokinin-responsive marker lines demonstrated that 4PBA specifically enhances AUXIN RESPONSE FACTOR (ARF)-dependent auxin responses. Our western blot analyses showed that 4PBA treatment does not enhance histone acetylation in Arabidop"],"journal":["Plant biotechnology (Tokyo, Japan)"],"pagination":["51-58"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9080989"],"repository":["biostudies-literature"],"pubmed_title":["4-Phenylbutyric acid promotes plant regeneration as an auxin by being converted to phenylacetic acid via an IBR3-independent pathway."],"pmcid":["PMC9080989"],"pubmed_authors":["Iwase A","Favero DS","Watanabe S","Aoi Y","Takebayashi A","Seo M","Sugimoto K","Kasahara H"],"additional_accession":[]},"is_claimable":false,"name":"4-Phenylbutyric acid promotes plant regeneration as an auxin by being converted to phenylacetic acid via an IBR3-independent pathway.","description":"4-Phenylbutyric acid (4PBA) is utilized as a drug to treat urea cycle disorders and is also being studied as a potential anticancer drug that acts via its histone deacetylase (HDAC) inhibitor activity. During a search to find small molecules that affect plant regeneration in Arabidopsis, we found that 4PBA treatment promotes this process by mimicking the effect of exogenous auxin. Specifically, plant tissue culture experiments revealed that a medium containing 4PBA enhances callus formation and subsequent shoot regeneration. Analyses with auxin-responsive or cytokinin-responsive marker lines demonstrated that 4PBA specifically enhances AUXIN RESPONSE FACTOR (ARF)-dependent auxin responses. Our western blot analyses showed that 4PBA treatment does not enhance histone acetylation in Arabidop","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2026-05-30T22:02:12.281Z","creation":"2022-07-12T04:10:15.859Z"},"accession":"S-EPMC9080989","cross_references":{"pubmed":["35601015"],"doi":["10.5511/plantbiotechnology.21.1224b"]}}