biostudies-literatureKreider-Letterman GNCI NIH HHSNIGMS NIH HHS151209https://www.ebi.ac.uk/biostudies/studies/S-EPMC9081277biostudies-literatureUnknown101(2)Cancer progression and metastasis are processes that involve significant cellular changes. Many of these changes include alterations in the activity of the Rho GTPase family of proteins. Rho GTPases are signaling proteins that function as molecular switches and are involved in the regulation of most major cellular processes. Cancer development is often associated with abnormalities in Rho GTPase signaling. Rho GTPase signaling is regulated by two families of proteins, guanine nucleotide-exchange factors (RhoGEFs) and GTPase activating proteins (RhoGAPs), that function upstream of the Rho proteins to regulate their activation and inactivation, respectively. While initial work has focused on the role of RhoGEFs in cancer, the RhoGAP family members are rapidly being established as key regulatEuropean journal of cell biologyFixing the GAP: The role of RhoGAPs in cancer.PMC9081277R03 CA234693R01 GM136826Kreider-Letterman GCarr NMGarcia-Mata RfalseFixing the GAP: The role of RhoGAPs in cancer.Cancer progression and metastasis are processes that involve significant cellular changes. Many of these changes include alterations in the activity of the Rho GTPase family of proteins. Rho GTPases are signaling proteins that function as molecular switches and are involved in the regulation of most major cellular processes. Cancer development is often associated with abnormalities in Rho GTPase signaling. Rho GTPase signaling is regulated by two families of proteins, guanine nucleotide-exchange factors (RhoGEFs) and GTPase activating proteins (RhoGAPs), that function upstream of the Rho proteins to regulate their activation and inactivation, respectively. While initial work has focused on the role of RhoGEFs in cancer, the RhoGAP family members are rapidly being established as key regulat2022-01-01T00:00:00Z2022 Apr2026-05-31T11:11:54.174Z2024-11-20T15:46:28.354ZS-EPMC90812773518056710.1016/j.ejcb.2022.151209