{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhu T"],"funding":["Major Science and Technology Projects in Yunnan Province"],"pagination":["867525"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9081565"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13"],"pubmed_abstract":["This study aimed to elucidate the mechanism of <i>Bletilla striata</i> oligosaccharides (BO) in the treatment of ulcerative colitis (UC). A UC mouse model was induced by 3% Dextran sodium sulfate (DSS), and BO (200 mg/kg/d) were administered for intervention. The results show that BO effectively inhibited the release of intestinal inflammatory cytokines such as IL-6, TNF-α, and IL-1β. Also, BO profoundly elevated the secretion of mucins and the expression of tight junction (TJ) proteins to attenuate dysfunction of the intestinal barrier. The 16S rDNA sequencing and liquid chromatography/gas chromatography-mass spectrometer (LC/GC-MS) analysis of mouse feces revealed that BO regulated the disturbance of gut microbiota and intestinal metabolites. By using the <i>in vitro</i> fermentation bro"],"journal":["Frontiers in pharmacology"],"pubmed_title":["<i>Bletilla striata</i> Oligosaccharides Improve Ulcerative Colitis by Regulating Gut Microbiota and Intestinal Metabolites in Dextran Sulfate Sodium-Induced Mice."],"pmcid":["PMC9081565"],"funding_grant_id":["202102AE090042"],"pubmed_authors":["Liu H","Liu Y","Li S","Zhang Z","Ye C","Hu H","Yin M","Hu B","Zhu T"],"additional_accession":[]},"is_claimable":false,"name":"<i>Bletilla striata</i> Oligosaccharides Improve Ulcerative Colitis by Regulating Gut Microbiota and Intestinal Metabolites in Dextran Sulfate Sodium-Induced Mice.","description":"This study aimed to elucidate the mechanism of <i>Bletilla striata</i> oligosaccharides (BO) in the treatment of ulcerative colitis (UC). A UC mouse model was induced by 3% Dextran sodium sulfate (DSS), and BO (200 mg/kg/d) were administered for intervention. The results show that BO effectively inhibited the release of intestinal inflammatory cytokines such as IL-6, TNF-α, and IL-1β. Also, BO profoundly elevated the secretion of mucins and the expression of tight junction (TJ) proteins to attenuate dysfunction of the intestinal barrier. The 16S rDNA sequencing and liquid chromatography/gas chromatography-mass spectrometer (LC/GC-MS) analysis of mouse feces revealed that BO regulated the disturbance of gut microbiota and intestinal metabolites. By using the <i>in vitro</i> fermentation bro","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-05T13:23:35.74Z","creation":"2025-02-19T03:27:28.018Z"},"accession":"S-EPMC9081565","cross_references":{"pubmed":["35548331"],"doi":["10.3389/fphar.2022.867525"]}}