{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li Y"],"funding":["Guangdong Innovative and Entrepreneurial Research Team Program","Natural Science Foundation of Guangdong Province","National Natural Science Foundation of China"],"pagination":["23623-23628"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9081827"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(42)"],"pubmed_abstract":["Recently, nanoscale metal organic frameworks have attracted considerable attention as a novel drug delivery system platform owing to their highly efficient drug loading and delivery capacities. However, their low dispersity in aqueous media, poor biocompatibility, and non-active targeting ability seriously limit their further clinical application. To address these issues, a hyaluronic acid (HA)-coated ZIF-8 nanocomposite (CCM@ZIF-8/HA) was successfully developed for use in anti-cancer treatment through efficient curcumin (CCM) delivery. The resultant CCM@ZIF-8/HA showed a long-term pH-dependent controlled drug release based on the core-shell structure of the encapsulation by HA. Moreover, compared to bare CCM@ZIF-8, the obtained ternary assembly showed enhanced dispersity in PBS, promoted "],"journal":["RSC advances"],"pubmed_title":["Biocompatible surface modification of nano-scale zeolitic imidazolate frameworks for enhanced drug delivery."],"pmcid":["PMC9081827"],"funding_grant_id":["2016A030310465","2013S086","2014A030312018","51503230"],"pubmed_authors":["Lai X","Li Y","Zheng Y","Chu Y","Chen Y"],"additional_accession":[]},"is_claimable":false,"name":"Biocompatible surface modification of nano-scale zeolitic imidazolate frameworks for enhanced drug delivery.","description":"Recently, nanoscale metal organic frameworks have attracted considerable attention as a novel drug delivery system platform owing to their highly efficient drug loading and delivery capacities. However, their low dispersity in aqueous media, poor biocompatibility, and non-active targeting ability seriously limit their further clinical application. To address these issues, a hyaluronic acid (HA)-coated ZIF-8 nanocomposite (CCM@ZIF-8/HA) was successfully developed for use in anti-cancer treatment through efficient curcumin (CCM) delivery. The resultant CCM@ZIF-8/HA showed a long-term pH-dependent controlled drug release based on the core-shell structure of the encapsulation by HA. Moreover, compared to bare CCM@ZIF-8, the obtained ternary assembly showed enhanced dispersity in PBS, promoted ","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jun","modification":"2025-04-06T19:47:01.548Z","creation":"2025-04-06T19:47:01.548Z"},"accession":"S-EPMC9081827","cross_references":{"pubmed":["35540287"],"doi":["10.1039/c8ra03616k"]}}