biostudies-literatureWu WNNational Natural Science Foundation of ChinaEducation Department of Henan Province5640-5646https://www.ebi.ac.uk/biostudies/studies/S-EPMC9082053biostudies-literatureUnknown8(10)A new colorimetric and fluorescence molecular chemosensor based on triazole hydrazone can be used as a multi-probe for selective detection of Al³⁺, Zn²⁺, and Cu²⁺ by monitoring changes in the absorption and fluorescence spectral patterns. Results show that Al³⁺ and Zn²⁺ ions can induce remarkable fluorescence enhancement at pH 6.0 and pH 10.0, respectively, while the addition of Cu²⁺ ions leads to a significant UV-visible absorption enhancement in the visible range at pH 6.0. In addition, the resultant Al³⁺ complex could act as an 'on-off' fluorescence sensor for F^-. The fluorescence sensor was also used to monitor intracellular Al³⁺, Zn²⁺, and F^- in Hela cells.RSC advancesA simple hydrazone as a multianalyte (Cu²⁺, Al³⁺, Zn²⁺) sensor at different pH values and the resultant Al³⁺ complex as a sensor for F.PMC908205315B15001615HASTIT00221001040Wu WNXu ZQMao XJZhao XLFan YCWang YXu ZHLiu BZWu HfalseA simple hydrazone as a multianalyte (Cu²⁺, Al³⁺, Zn²⁺) sensor at different pH values and the resultant Al³⁺ complex as a sensor for F.A new colorimetric and fluorescence molecular chemosensor based on triazole hydrazone can be used as a multi-probe for selective detection of Al³⁺, Zn²⁺, and Cu²⁺ by monitoring changes in the absorption and fluorescence spectral patterns. Results show that Al³⁺ and Zn²⁺ ions can induce remarkable fluorescence enhancement at pH 6.0 and pH 10.0, respectively, while the addition of Cu²⁺ ions leads to a significant UV-visible absorption enhancement in the visible range at pH 6.0. In addition, the resultant Al³⁺ complex could act as an 'on-off' fluorescence sensor for F^-. The fluorescence sensor was also used to monitor intracellular Al³⁺, Zn²⁺, and F^- in Hela cells.2018-01-01T00:00:00Z2018 Jan2025-04-06T19:46:38.159Z2025-04-06T19:46:38.159ZS-EPMC90820533554243510.1039/c7ra10219d