{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(2)"],"submitter":["Jarahian M"],"pubmed_abstract":["Expression of the extensively glycosylated Ebolavirus glycoprotein (EBOV-GP) induces physical alterations of surface molecules and plays a crucial role in viral pathogenicity. Here we investigate the interactions of EBOV-GP with host surface molecules using purified EBOV-GP, EBOV-GP-transfected cell lines, and EBOV-GP-pseudotyped lentiviral particles. Subsequently, we wanted to examine which receptors are involved in this recognition by binding studies to cells transfected with the EBOV-GP as well as to recombinant soluble EBOV-GP. As the viral components can also bind to inhibitory receptors of immune cells (e.g., Siglecs, TIM-1), they can even suppress the activity of immune effector cells. Our data show that natural killer (NK) cell receptors NKp44 and NKp46, selectins (CD62E/P/L), the "],"journal":["Journal of innate immunity"],"pagination":["135-147"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9082198"],"repository":["biostudies-literature"],"pubmed_title":["Activating Natural Killer Cell Receptors, Selectins, and Inhibitory Siglecs Recognize Ebolavirus Glycoprotein."],"pmcid":["PMC9082198"],"pubmed_authors":["Marstaller K","Ahani R","Watzl C","Banna N","Boller LK","Cid-Arregui A","Berger MR","Jarahian M","Azadmanesh K","Momburg F","Khezri A","Etemadzadeh MH"],"additional_accession":[]},"is_claimable":false,"name":"Activating Natural Killer Cell Receptors, Selectins, and Inhibitory Siglecs Recognize Ebolavirus Glycoprotein.","description":"Expression of the extensively glycosylated Ebolavirus glycoprotein (EBOV-GP) induces physical alterations of surface molecules and plays a crucial role in viral pathogenicity. Here we investigate the interactions of EBOV-GP with host surface molecules using purified EBOV-GP, EBOV-GP-transfected cell lines, and EBOV-GP-pseudotyped lentiviral particles. Subsequently, we wanted to examine which receptors are involved in this recognition by binding studies to cells transfected with the EBOV-GP as well as to recombinant soluble EBOV-GP. As the viral components can also bind to inhibitory receptors of immune cells (e.g., Siglecs, TIM-1), they can even suppress the activity of immune effector cells. Our data show that natural killer (NK) cell receptors NKp44 and NKp46, selectins (CD62E/P/L), the ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-26T03:54:50.005Z","creation":"2025-02-19T03:41:50.186Z"},"accession":"S-EPMC9082198","cross_references":{"pubmed":["34425576"],"doi":["10.1159/000517628"]}}