biostudies-literatureHo FKNHS Research Scotland Senior Clinical FellowshipUK Biobank was established by the Wellcome Trust Medical Research CouncilMedical Research CouncilChief Scientist OfficeDepartment of Health, Scottish government and the Northwest Regional Development AgencyWellcome TrustGlasgow’s Wellcome Trust Institutional Strategic Support Fund Early Career Researcher Catalyst579-590https://www.ebi.ac.uk/biostudies/studies/S-EPMC9082805biostudies-literatureUnknown51(2)<h4>Background</h4>This study aimed to study the association between shift work and incident and fatal cardiovascular disease (CVD), and to explore modifying and mediating factors.<h4>Methods</h4>This is a population-based, prospective cohort study with a median follow-up of 11 years; 238 661 UK Biobank participants who were in paid employment or self-employed at baseline assessment were included.<h4>Results</h4>Shift workers had higher risk of incident [hazard ratio (HR) 1.11, 95% confidence interval (CI) 1.06-1.19] and fatal (HR 1.25, 95% CI 1.08-1.44) CVD compared with non-shift workers, after adjusting for socio-economic and work-related factors. The risk was higher with longer duration of shift work, in women and in jobs with little heavy manual labour. Current smoking, short sleep duInternational journal of epidemiologyAssociation and pathways between shift work and cardiovascular disease: a prospective cohort study of 238 661 participants from UK Biobank.PMC9082805MC_PC_17228SPHSU17SPHSU13MC_UU_12017/13SCAF/15/02MC_QA137853MC_UU_00022/2Mackay DDemou EKatikireddi SVHo FKCelis-Morales CWelsh PGray SRSattar NPell JPfalseAssociation and pathways between shift work and cardiovascular disease: a prospective cohort study of 238 661 participants from UK Biobank.<h4>Background</h4>This study aimed to study the association between shift work and incident and fatal cardiovascular disease (CVD), and to explore modifying and mediating factors.<h4>Methods</h4>This is a population-based, prospective cohort study with a median follow-up of 11 years; 238 661 UK Biobank participants who were in paid employment or self-employed at baseline assessment were included.<h4>Results</h4>Shift workers had higher risk of incident [hazard ratio (HR) 1.11, 95% confidence interval (CI) 1.06-1.19] and fatal (HR 1.25, 95% CI 1.08-1.44) CVD compared with non-shift workers, after adjusting for socio-economic and work-related factors. The risk was higher with longer duration of shift work, in women and in jobs with little heavy manual labour. Current smoking, short sleep du2022-01-01T00:00:00Z2022 May2026-07-14T16:45:03.713Z2025-04-04T09:10:09.268ZS-EPMC90828053441442810.1093/ije/dyab144