{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang L"],"funding":["National Natural Science Foundation of China"],"pagination":["26538-26548"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9083100"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(47)"],"pubmed_abstract":["Exposure to nanoparticles may lead to pneumoconiosis and lung cancer; however, whether patients suffering from pneumoconiosis also face a high risk of lung cancer has been under debate for decades. Recently, exosomes have been found to play critical roles in many diseases <i>via</i> intercellular cargo transportation, which has provided a new insight into the mechanistic investigation of nanoparticle-induced respiratory disorders. Herein, we isolated exosomes from the venous blood of patients with pneumoconiosis and healthy controls and then, we profiled the expression signatures of exosomal miRNAs using high-throughput sequencing technology. A total of 14 aberrantly expressed miRNAs were identified and used to process target gene prediction and functional annotation. Specially, miR-125a a"],"journal":["RSC advances"],"pubmed_title":["Up-regulation of exosomal miR-125a in pneumoconiosis inhibits lung cancer development by suppressing expressions of EZH2 and hnRNPK."],"pmcid":["PMC9083100"],"funding_grant_id":["81773404","81273039","81472954"],"pubmed_authors":["Li J","Zhang J","Guo W","Wang D","Duan S","Zhang L","Hao C","Yao W","Zhao Y"],"additional_accession":[]},"is_claimable":false,"name":"Up-regulation of exosomal miR-125a in pneumoconiosis inhibits lung cancer development by suppressing expressions of EZH2 and hnRNPK.","description":"Exposure to nanoparticles may lead to pneumoconiosis and lung cancer; however, whether patients suffering from pneumoconiosis also face a high risk of lung cancer has been under debate for decades. Recently, exosomes have been found to play critical roles in many diseases <i>via</i> intercellular cargo transportation, which has provided a new insight into the mechanistic investigation of nanoparticle-induced respiratory disorders. Herein, we isolated exosomes from the venous blood of patients with pneumoconiosis and healthy controls and then, we profiled the expression signatures of exosomal miRNAs using high-throughput sequencing technology. A total of 14 aberrantly expressed miRNAs were identified and used to process target gene prediction and functional annotation. Specially, miR-125a a","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jul","modification":"2026-05-30T20:53:43.35Z","creation":"2025-04-04T10:01:41.701Z"},"accession":"S-EPMC9083100","cross_references":{"pubmed":["35541090"],"doi":["10.1039/c8ra03081b"]}}