{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tamaki M"],"funding":["Japan Society for the Promotion of Science"],"pagination":["28147-28151"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9084302"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(49)"],"pubmed_abstract":["Dendrimers are unique polymers with well-defined structures, and are useful as functional unimolecular nanoparticles. Previous reports have shown that polyamidoamine (PAMAM) dendrimers modified with hydrophobic molecules, such as amino-terminal phenylalanine (Phe), are thermosensitive at high pH. In the present study, we designed carboxyl-terminal Phe-modified PAMAM dendrimers that are thermosensitive under acidic conditions. We reacted an amino-terminal PAMAM dendrimer with various acid anhydrides, such as succinic anhydride, cyclohexanedicarboxylic anhydride, and phthalic anhydride, prior to the reaction with Phe. Interestingly, the amino-terminal Phe-modified PAMAM dendrimers exhibited LCST (lower critical solution temperature)-type thermosensitivity at approximately pH 7, but the carbo"],"journal":["RSC advances"],"pubmed_title":["Dual pH-sensitive and UCST-type thermosensitive dendrimers: phenylalanine-modified polyamidoamine dendrimers with carboxyl termini."],"pmcid":["PMC9084302"],"funding_grant_id":["Scientific Research (C)/No. 17K06004"],"pubmed_authors":["Kojima C","Tamaki M","Fukushima D"],"additional_accession":[]},"is_claimable":false,"name":"Dual pH-sensitive and UCST-type thermosensitive dendrimers: phenylalanine-modified polyamidoamine dendrimers with carboxyl termini.","description":"Dendrimers are unique polymers with well-defined structures, and are useful as functional unimolecular nanoparticles. Previous reports have shown that polyamidoamine (PAMAM) dendrimers modified with hydrophobic molecules, such as amino-terminal phenylalanine (Phe), are thermosensitive at high pH. In the present study, we designed carboxyl-terminal Phe-modified PAMAM dendrimers that are thermosensitive under acidic conditions. We reacted an amino-terminal PAMAM dendrimer with various acid anhydrides, such as succinic anhydride, cyclohexanedicarboxylic anhydride, and phthalic anhydride, prior to the reaction with Phe. Interestingly, the amino-terminal Phe-modified PAMAM dendrimers exhibited LCST (lower critical solution temperature)-type thermosensitivity at approximately pH 7, but the carbo","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Aug","modification":"2025-04-19T13:20:46.676Z","creation":"2025-04-19T13:20:46.676Z"},"accession":"S-EPMC9084302","cross_references":{"pubmed":["35542750"],"doi":["10.1039/c8ra05381b"]}}