biostudies-literatureUnknown13Jasinska-Mikolajczyk A<h4>Background</h4>Cognitive deficits occur in most patients with affective disorders. The role of neurotrophic factors (e.g., BDNF) as modulators of brain plasticity affecting neurocognitive abilities has been emphasized. Neurotrophin concentrations may change under the influence of various interventions, including physical activity. Selected studies have shown that cognitive function may also be affected by exercise.<h4>Aim</h4>The aim of the study was to determine whether physical activity changes the concentration of neurotrophins and their receptors in patients with an episode of depression. It was also examined how one session of aerobic exercise affects cognitive control.<h4>Methods</h4>The study included 41 participants. The subjects were asked to exercise on a cycloergometer for 4Frontiers in psychiatry777394https://www.ebi.ac.uk/biostudies/studies/S-EPMC9084496biostudies-literatureThe Effect of Physical Activity on Neurotrophin Concentrations and Cognitive Control in Patients With a Depressive Episode.PMC9084496Skibinska MDrews KRybakowski FJowik KJasinska-Mikolajczyk AKonofalska MKolasa GDomaszewska KfalseThe Effect of Physical Activity on Neurotrophin Concentrations and Cognitive Control in Patients With a Depressive Episode.<h4>Background</h4>Cognitive deficits occur in most patients with affective disorders. The role of neurotrophic factors (e.g., BDNF) as modulators of brain plasticity affecting neurocognitive abilities has been emphasized. Neurotrophin concentrations may change under the influence of various interventions, including physical activity. Selected studies have shown that cognitive function may also be affected by exercise.<h4>Aim</h4>The aim of the study was to determine whether physical activity changes the concentration of neurotrophins and their receptors in patients with an episode of depression. It was also examined how one session of aerobic exercise affects cognitive control.<h4>Methods</h4>The study included 41 participants. The subjects were asked to exercise on a cycloergometer for 42022-01-01T00:00:00Z20222025-04-19T13:19:37.047Z2024-11-20T15:42:55.63ZS-EPMC90844963554692110.3389/fpsyt.2022.777394