{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(1)"],"submitter":["Freuer D"],"pubmed_abstract":["Emerging evidence from observational studies suggests an increased risk of Parkinson's disease (PD) in patients with inflammatory bowel disease (IBD). However, to date it is not clear whether a causal relationship exists. To investigate whether IBD is causally related to PD, a two-sample Mendelian randomization study was carried out. Independent genetic instruments from the largest available genome-wide association study (GWAS) for IBD (7045 cases, 456,327 controls) including European participants were used to investigate the association with PD (56,306 cases; 1.4 million controls). The results were validated by using a second IBD sample (12,882 cases; 21,770 controls) including the main subtypes ulcerative colitis (UC; 6968 cases; 20,464 controls) and Crohn's disease (CD; 5956 cases; 14,9"],"journal":["NPJ Parkinson's disease"],"pagination":["55"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9085764"],"repository":["biostudies-literature"],"pubmed_title":["Association between inflammatory bowel disease and Parkinson's disease: A Mendelian randomization study."],"pmcid":["PMC9085764"],"pubmed_authors":["Meisinger C","Freuer D"],"additional_accession":[]},"is_claimable":false,"name":"Association between inflammatory bowel disease and Parkinson's disease: A Mendelian randomization study.","description":"Emerging evidence from observational studies suggests an increased risk of Parkinson's disease (PD) in patients with inflammatory bowel disease (IBD). However, to date it is not clear whether a causal relationship exists. To investigate whether IBD is causally related to PD, a two-sample Mendelian randomization study was carried out. Independent genetic instruments from the largest available genome-wide association study (GWAS) for IBD (7045 cases, 456,327 controls) including European participants were used to investigate the association with PD (56,306 cases; 1.4 million controls). The results were validated by using a second IBD sample (12,882 cases; 21,770 controls) including the main subtypes ulcerative colitis (UC; 6968 cases; 20,464 controls) and Crohn's disease (CD; 5956 cases; 14,9","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2026-03-27T15:18:03.771Z","creation":"2025-04-04T19:09:55.994Z"},"accession":"S-EPMC9085764","cross_references":{"pubmed":["35534507"],"doi":["10.1038/s41531-022-00318-7"]}}