{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Umeton R"],"funding":["Fondazione Italiana Sclerosi Multipla","National Multiple Sclerosis Society","Sapienza Università di Roma"],"pagination":["7536"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9085834"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["A clinically actionable understanding of multiple sclerosis (MS) etiology goes through GWAS interpretation, prompting research on new gene regulatory models. Our previous investigations suggested heterogeneity in etiology components and stochasticity in the interaction between genetic and non-genetic factors. To find a unifying model for this evidence, we focused on the recently mapped transient transcriptome (TT), that is mostly coded by intergenic and intronic regions, with half-life of minutes. Through a colocalization analysis, here we demonstrate that genomic regions coding for the TT are significantly enriched for MS-associated GWAS variants and DNA binding sites for molecular transducers mediating putative, non-genetic, determinants of MS (vitamin D deficiency, Epstein Barr virus la"],"journal":["Scientific reports"],"pubmed_title":["Multiple sclerosis genetic and non-genetic factors interact through the transient transcriptome."],"pmcid":["PMC9085834"],"funding_grant_id":["Progetti Grande Ateneo"],"pubmed_authors":["Mechelli R","Ristori G","Umeton R","Rinaldi V","Salvetti M","Pizzolato Umeton R","Bellucci G","Buscarinu MC","Romano C","Bigi R","Morena E","Romano S","Renie R"],"additional_accession":[]},"is_claimable":false,"name":"Multiple sclerosis genetic and non-genetic factors interact through the transient transcriptome.","description":"A clinically actionable understanding of multiple sclerosis (MS) etiology goes through GWAS interpretation, prompting research on new gene regulatory models. Our previous investigations suggested heterogeneity in etiology components and stochasticity in the interaction between genetic and non-genetic factors. To find a unifying model for this evidence, we focused on the recently mapped transient transcriptome (TT), that is mostly coded by intergenic and intronic regions, with half-life of minutes. Through a colocalization analysis, here we demonstrate that genomic regions coding for the TT are significantly enriched for MS-associated GWAS variants and DNA binding sites for molecular transducers mediating putative, non-genetic, determinants of MS (vitamin D deficiency, Epstein Barr virus la","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2026-05-31T12:59:59.892Z","creation":"2025-04-06T21:51:29.001Z"},"accession":"S-EPMC9085834","cross_references":{"pubmed":["35534508"],"doi":["10.1038/s41598-022-11444-w"]}}