{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Valk SL"],"funding":["NIMH NIH HHS","NIH HHS","CIHR"],"pagination":["2341"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9085871"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["Brain structure scaffolds intrinsic function, supporting cognition and ultimately behavioral flexibility. However, it remains unclear how a static, genetically controlled architecture supports flexible cognition and behavior. Here, we synthesize genetic, phylogenetic and cognitive analyses to understand how the macroscale organization of structure-function coupling across the cortex can inform its role in cognition. In humans, structure-function coupling was highest in regions of unimodal cortex and lowest in transmodal cortex, a pattern that was mirrored by a reduced alignment with heritable connectivity profiles. Structure-function uncoupling in macaques had a similar spatial distribution, but we observed an increased coupling between structure and function in association cortices relati"],"journal":["Nature communications"],"pubmed_title":["Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex."],"pmcid":["PMC9085871"],"funding_grant_id":["S10 OD023696","R01 MH083246","RF1 MH123163","R01 MH074457","FDN-154298","R01 MH081218","U54 MH091657","R21 MH084126","R01 MH094639"],"pubmed_authors":["Bethlehem RAI","Smallwood J","Yeo BTT","Eickhoff SB","Bayrak S","Valk SL","Masouleh SK","Kochunov P","Bernhardt BC","Margulies D","Royer J","Vos de Wael R","Xu T","Paquola C","Park BY"],"additional_accession":[]},"is_claimable":false,"name":"Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex.","description":"Brain structure scaffolds intrinsic function, supporting cognition and ultimately behavioral flexibility. However, it remains unclear how a static, genetically controlled architecture supports flexible cognition and behavior. Here, we synthesize genetic, phylogenetic and cognitive analyses to understand how the macroscale organization of structure-function coupling across the cortex can inform its role in cognition. In humans, structure-function coupling was highest in regions of unimodal cortex and lowest in transmodal cortex, a pattern that was mirrored by a reduced alignment with heritable connectivity profiles. Structure-function uncoupling in macaques had a similar spatial distribution, but we observed an increased coupling between structure and function in association cortices relati","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-04T07:47:23.448Z","creation":"2025-04-04T07:47:23.448Z"},"accession":"S-EPMC9085871","cross_references":{"pubmed":["35534454"],"doi":["10.1038/s41467-022-29886-1"]}}