biostudies-literatureUnknown9Kuo JY<h4>Background</h4>Heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF) commonly coexist with overlapping pathophysiology like left atrial (LA) remodeling, which might differ given different underlying mechanisms.<h4>Objectives</h4>We sought to investigate the different patterns of LA wall remodeling in AF vs. HFpEF.<h4>Methods</h4>We compared LA wall characteristics including wall volume (LAWV), wall thickness (LAWT), and wall thickness heterogeneity (LAWT[SD]) and LA structure, function among the controls (without AF or HFpEF, <i>n</i> = 115), HFpEF alone (<i>n</i> = 59), AF alone (<i>n</i> = 37), and HFpEF+AF (<i>n</i> = 38) groups using multi-detector computed tomography and echocardiography.<h4>Results</h4>LA wall remodeling was most predominant and peakFrontiers in cardiovascular medicine857360https://www.ebi.ac.uk/biostudies/studies/S-EPMC9086706biostudies-literatureInsights on Distinct Left Atrial Remodeling Between Atrial Fibrillation and Heart Failure With Preserved Ejection Fraction.PMC9086706Chang SCJin XSun JYHung CLSung KTWu THMok GSPChi PCYun CHYu CHKuo JYLam CSPChang SHChung FPYeh HIfalseInsights on Distinct Left Atrial Remodeling Between Atrial Fibrillation and Heart Failure With Preserved Ejection Fraction.<h4>Background</h4>Heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF) commonly coexist with overlapping pathophysiology like left atrial (LA) remodeling, which might differ given different underlying mechanisms.<h4>Objectives</h4>We sought to investigate the different patterns of LA wall remodeling in AF vs. HFpEF.<h4>Methods</h4>We compared LA wall characteristics including wall volume (LAWV), wall thickness (LAWT), and wall thickness heterogeneity (LAWT[SD]) and LA structure, function among the controls (without AF or HFpEF, <i>n</i> = 115), HFpEF alone (<i>n</i> = 59), AF alone (<i>n</i> = 37), and HFpEF+AF (<i>n</i> = 38) groups using multi-detector computed tomography and echocardiography.<h4>Results</h4>LA wall remodeling was most predominant and peak2022-01-01T00:00:00Z20222025-04-04T07:44:06.888Z2025-04-04T07:44:06.888ZS-EPMC90867063555754410.3389/fcvm.2022.857360