{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Lismont C"],"pubmed_abstract":["The involvement of peroxisomes in cellular hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) metabolism has been a central theme since their first biochemical characterization by Christian de Duve in 1965. While the role of H<sub>2</sub>O<sub>2</sub> substantially changed from an exclusively toxic molecule to a signaling messenger, the regulatory role of peroxisomes in these signaling events is still largely underappreciated. This is mainly because the number of known protein targets of peroxisome-derived H<sub>2</sub>O<sub>2</sub> is rather limited and testing of specific targets is predominantly based on knowledge previously gathered in related fields of research. To gain a broader and more systematic insight into the role of peroxisomes in redox signaling, new approaches are urgently neede"],"journal":["Frontiers in cell and developmental biology"],"pagination":["888873"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9086853"],"repository":["biostudies-literature"],"pubmed_title":["Peroxisome-Derived Hydrogen Peroxide Modulates the Sulfenylation Profiles of Key Redox Signaling Proteins in Flp-In T-REx 293 Cells."],"pmcid":["PMC9086853"],"pubmed_authors":["Li H","Costa CF","Derua R","Fransen M","Lenaerts L","Revenco I","Hussein MAF","Van Veldhoven PP","Lismont C","Knoops B","De Bie J"],"additional_accession":[]},"is_claimable":false,"name":"Peroxisome-Derived Hydrogen Peroxide Modulates the Sulfenylation Profiles of Key Redox Signaling Proteins in Flp-In T-REx 293 Cells.","description":"The involvement of peroxisomes in cellular hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) metabolism has been a central theme since their first biochemical characterization by Christian de Duve in 1965. While the role of H<sub>2</sub>O<sub>2</sub> substantially changed from an exclusively toxic molecule to a signaling messenger, the regulatory role of peroxisomes in these signaling events is still largely underappreciated. This is mainly because the number of known protein targets of peroxisome-derived H<sub>2</sub>O<sub>2</sub> is rather limited and testing of specific targets is predominantly based on knowledge previously gathered in related fields of research. To gain a broader and more systematic insight into the role of peroxisomes in redox signaling, new approaches are urgently neede","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T14:41:59.443Z","creation":"2025-02-18T23:19:14.196Z"},"accession":"S-EPMC9086853","cross_references":{"pubmed":["35557958"],"doi":["10.3389/fcell.2022.888873"]}}