biostudies-literatureUnknown10Lismont CThe involvement of peroxisomes in cellular hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) metabolism has been a central theme since their first biochemical characterization by Christian de Duve in 1965. While the role of H<sub>2</sub>O<sub>2</sub> substantially changed from an exclusively toxic molecule to a signaling messenger, the regulatory role of peroxisomes in these signaling events is still largely underappreciated. This is mainly because the number of known protein targets of peroxisome-derived H<sub>2</sub>O<sub>2</sub> is rather limited and testing of specific targets is predominantly based on knowledge previously gathered in related fields of research. To gain a broader and more systematic insight into the role of peroxisomes in redox signaling, new approaches are urgently needeFrontiers in cell and developmental biology888873https://www.ebi.ac.uk/biostudies/studies/S-EPMC9086853biostudies-literaturePeroxisome-Derived Hydrogen Peroxide Modulates the Sulfenylation Profiles of Key Redox Signaling Proteins in Flp-In T-REx 293 Cells.PMC9086853Li HCosta CFDerua RFransen MLenaerts LRevenco IHussein MAFVan Veldhoven PPLismont CKnoops BDe Bie JfalsePeroxisome-Derived Hydrogen Peroxide Modulates the Sulfenylation Profiles of Key Redox Signaling Proteins in Flp-In T-REx 293 Cells.The involvement of peroxisomes in cellular hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) metabolism has been a central theme since their first biochemical characterization by Christian de Duve in 1965. While the role of H<sub>2</sub>O<sub>2</sub> substantially changed from an exclusively toxic molecule to a signaling messenger, the regulatory role of peroxisomes in these signaling events is still largely underappreciated. This is mainly because the number of known protein targets of peroxisome-derived H<sub>2</sub>O<sub>2</sub> is rather limited and testing of specific targets is predominantly based on knowledge previously gathered in related fields of research. To gain a broader and more systematic insight into the role of peroxisomes in redox signaling, new approaches are urgently neede2022-01-01T00:00:00Z20222025-04-04T14:41:59.443Z2025-02-18T23:19:14.196ZS-EPMC90868533555795810.3389/fcell.2022.888873