biostudies-literatureUnknown50(4)Bauer A<h4>Objective</h4>Clinical research has faced new challenges during the COVID-19 pandemic, leading to excessive operational demands affecting all stakeholders. We evaluated the impact of COVID-19 on clinical research strategies and compared different adaptations by regulatory bodies and academic research institutions in a global context, exploring what can be learned for possible future pandemics.<h4>Methods</h4>We conducted a cross-sectional online survey and identified and assessed different COVID-19-specific adaptation strategies used by academic research institutions and regulatory bodies.<h4>Results</h4>All 19 participating academic research institutions developed and followed similar strategies, including preventive measures, manpower recruitment, and prioritisation of COVID-19 projeThe Journal of international medical research3000605221093179https://www.ebi.ac.uk/biostudies/studies/S-EPMC9087250biostudies-literatureHow COVID-19 changed clinical research strategies: a global survey.PMC9087250Uresin YEberle DStockley LBauer AYau HGrossmann RNtekim AEskat ASen SWong CEgert-Schwender Sde Medina Redondo MHedayati ETay FfalseHow COVID-19 changed clinical research strategies: a global survey.<h4>Objective</h4>Clinical research has faced new challenges during the COVID-19 pandemic, leading to excessive operational demands affecting all stakeholders. We evaluated the impact of COVID-19 on clinical research strategies and compared different adaptations by regulatory bodies and academic research institutions in a global context, exploring what can be learned for possible future pandemics.<h4>Methods</h4>We conducted a cross-sectional online survey and identified and assessed different COVID-19-specific adaptation strategies used by academic research institutions and regulatory bodies.<h4>Results</h4>All 19 participating academic research institutions developed and followed similar strategies, including preventive measures, manpower recruitment, and prioritisation of COVID-19 proje2022-01-01T00:00:00Z2022 Apr2025-04-04T07:32:40.377Z2025-04-04T07:32:40.377ZS-EPMC90872503546947310.1177/03000605221093179