{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Li Q"],"pubmed_abstract":["Attention-deficit/hyperactivity disorder (ADHD) is one of the most prevalent and heritable childhood behavioral disorders. Although a number of ADHD-susceptible regions had been identified, details about the variations of genes and their related patterns involved in ADHD are still lacking. In this study, we collected 25 Chinese parents-offspring trios, each of which consisted of a child diagnosed with ADHD and his/her unaffected parents, and analyzed the variations from whole-genome sequencing data. SNVs in reported ADHD-susceptible regions and on the genes whose functions were related to dopamine were screened, and we identified a set of variants with functional annotations which were specifically detected in ADHD children, including most SNVs in the gene coding region that might impair p"],"journal":["Frontiers in genetics"],"pagination":["878036"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9087589"],"repository":["biostudies-literature"],"pubmed_title":["A Systematic Screening of ADHD-Susceptible Variants From 25 Chinese Parents-Offspring Trios."],"pmcid":["PMC9087589"],"pubmed_authors":["Xie Y","Li T","Li Q","Sun W","Meng Y","Wang J"],"additional_accession":[]},"is_claimable":false,"name":"A Systematic Screening of ADHD-Susceptible Variants From 25 Chinese Parents-Offspring Trios.","description":"Attention-deficit/hyperactivity disorder (ADHD) is one of the most prevalent and heritable childhood behavioral disorders. Although a number of ADHD-susceptible regions had been identified, details about the variations of genes and their related patterns involved in ADHD are still lacking. In this study, we collected 25 Chinese parents-offspring trios, each of which consisted of a child diagnosed with ADHD and his/her unaffected parents, and analyzed the variations from whole-genome sequencing data. SNVs in reported ADHD-susceptible regions and on the genes whose functions were related to dopamine were screened, and we identified a set of variants with functional annotations which were specifically detected in ADHD children, including most SNVs in the gene coding region that might impair p","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-31T13:00:03.85Z","creation":"2025-04-06T21:51:36.285Z"},"accession":"S-EPMC9087589","cross_references":{"pubmed":["35559026"],"doi":["10.3389/fgene.2022.878036"]}}