biostudies-literatureUnknown13Li QAttention-deficit/hyperactivity disorder (ADHD) is one of the most prevalent and heritable childhood behavioral disorders. Although a number of ADHD-susceptible regions had been identified, details about the variations of genes and their related patterns involved in ADHD are still lacking. In this study, we collected 25 Chinese parents-offspring trios, each of which consisted of a child diagnosed with ADHD and his/her unaffected parents, and analyzed the variations from whole-genome sequencing data. SNVs in reported ADHD-susceptible regions and on the genes whose functions were related to dopamine were screened, and we identified a set of variants with functional annotations which were specifically detected in ADHD children, including most SNVs in the gene coding region that might impair pFrontiers in genetics878036https://www.ebi.ac.uk/biostudies/studies/S-EPMC9087589biostudies-literatureA Systematic Screening of ADHD-Susceptible Variants From 25 Chinese Parents-Offspring Trios.PMC9087589Xie YLi TLi QSun WMeng YWang JfalseA Systematic Screening of ADHD-Susceptible Variants From 25 Chinese Parents-Offspring Trios.Attention-deficit/hyperactivity disorder (ADHD) is one of the most prevalent and heritable childhood behavioral disorders. Although a number of ADHD-susceptible regions had been identified, details about the variations of genes and their related patterns involved in ADHD are still lacking. In this study, we collected 25 Chinese parents-offspring trios, each of which consisted of a child diagnosed with ADHD and his/her unaffected parents, and analyzed the variations from whole-genome sequencing data. SNVs in reported ADHD-susceptible regions and on the genes whose functions were related to dopamine were screened, and we identified a set of variants with functional annotations which were specifically detected in ADHD children, including most SNVs in the gene coding region that might impair p2022-01-01T00:00:00Z20222026-05-31T13:00:03.85Z2025-04-06T21:51:36.285ZS-EPMC90875893555902610.3389/fgene.2022.878036