biostudies-literaturePrabhakar AScience and Engineering Research BoardIndian Institute of Technology BombayDepartment of Science and Technology, Ministry of Science and Technology35539-35550https://www.ebi.ac.uk/biostudies/studies/S-EPMC9088425biostudies-literatureUnknown8(62)U or C-shaped waveguides, coupled to analyte microchannels, have been shown to be very responsive to evanescent-wave-absorption-based sensing. However, due to only having a single C-bend length, for analyte interaction in earlier devices, there was always an opportunity to advance their evanescent-absorbance sensitivity, by including multiple C-bend structures (interfaced with the analyte microchannel system) in the device design. To achieve this objective, two different types of waveguide probes (having a different orientation of two C-bends), <i>i.e.</i> S-bend and spiral-bend, were theoretically analyzed and further, experimentally tested for their comparative sensitivity to evanescent wave absorption, in this pioneering study. A novel single-step fabrication procedure (using an SU-8 phRSC advancesInvestigation of dual-bend serpentine/spiral waveguides coupled to a microchannel system for competent, evanescent-wave-absorption-based, on-chip, biological-/chemical-sensing applications.PMC9088425SR/FTP/ETA-0126/2014DST/TM/WTI/2K15/201Verma DMukherji SMishra NPrabhakar AfalseInvestigation of dual-bend serpentine/spiral waveguides coupled to a microchannel system for competent, evanescent-wave-absorption-based, on-chip, biological-/chemical-sensing applications.U or C-shaped waveguides, coupled to analyte microchannels, have been shown to be very responsive to evanescent-wave-absorption-based sensing. However, due to only having a single C-bend length, for analyte interaction in earlier devices, there was always an opportunity to advance their evanescent-absorbance sensitivity, by including multiple C-bend structures (interfaced with the analyte microchannel system) in the device design. To achieve this objective, two different types of waveguide probes (having a different orientation of two C-bends), <i>i.e.</i> S-bend and spiral-bend, were theoretically analyzed and further, experimentally tested for their comparative sensitivity to evanescent wave absorption, in this pioneering study. A novel single-step fabrication procedure (using an SU-8 ph2018-01-01T00:00:00Z2018 Oct2025-04-27T01:09:28.813Z2025-04-06T18:03:16.28ZS-EPMC90884253555800110.1039/c8ra06527f