biostudies-literatureNaraga AMBDepartment of Science and Technology36579-36583https://www.ebi.ac.uk/biostudies/studies/S-EPMC9088864biostudies-literatureUnknown8(64)The total synthesis of μ-conotoxin lt5d is presented for the first time employing two different strategies. One involves glutathione-assisted oxidation where all disulphide linkages are formed simultaneously. Another involves orthogonal protection of cysteine residues, allowing the controlled formation of disulphide linkages sequentially. Both methods achieve the same peptide.RSC advancesTotal synthesis of μ-conotoxin lt5d.PMC9088864FP140015Naraga AMBVillaraza AJLBelleza OJVfalseTotal synthesis of μ-conotoxin lt5d.The total synthesis of μ-conotoxin lt5d is presented for the first time employing two different strategies. One involves glutathione-assisted oxidation where all disulphide linkages are formed simultaneously. Another involves orthogonal protection of cysteine residues, allowing the controlled formation of disulphide linkages sequentially. Both methods achieve the same peptide.2018-01-01T00:00:00Z2018 Oct2026-05-30T20:54:44.849Z2025-04-04T10:02:09.266ZS-EPMC90888643555893710.1039/c8ra03706j