{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(66)"],"submitter":["Ibrahim HM"],"pubmed_abstract":["The efficient, highly convenient synthesis of polysubstituted pyridine derivatives was established <i>via</i> the reaction of <i>N</i>-(benzothiazol-2-yl)-2-cyanoacetamides with an assortment of arylidene malononitriles and arylidene ethyl cyanoacetates in the presence of l-proline as an efficient organocatalyst for this type of ultrasonic-mediated Michael addition. The mechanistic pathway and factors affecting this reaction were also established. The main characteristics of this procedure are high yields, use of a cost-effective catalyst, and easy work-up and purification."],"journal":["RSC advances"],"pagination":["37606-37617"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9089412"],"repository":["biostudies-literature"],"pubmed_title":["l-Proline catalyzed one-pot synthesis of polysubstituted pyridine system incorporating benzothiazole moiety <i>via</i> sustainable sonochemical approach."],"pmcid":["PMC9089412"],"pubmed_authors":["Ahmed Arafa WA","Behbehani H","Ibrahim HM"],"additional_accession":[]},"is_claimable":false,"name":"l-Proline catalyzed one-pot synthesis of polysubstituted pyridine system incorporating benzothiazole moiety <i>via</i> sustainable sonochemical approach.","description":"The efficient, highly convenient synthesis of polysubstituted pyridine derivatives was established <i>via</i> the reaction of <i>N</i>-(benzothiazol-2-yl)-2-cyanoacetamides with an assortment of arylidene malononitriles and arylidene ethyl cyanoacetates in the presence of l-proline as an efficient organocatalyst for this type of ultrasonic-mediated Michael addition. The mechanistic pathway and factors affecting this reaction were also established. The main characteristics of this procedure are high yields, use of a cost-effective catalyst, and easy work-up and purification.","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Nov","modification":"2026-06-04T17:06:53.806Z","creation":"2024-12-04T00:19:58.92Z"},"accession":"S-EPMC9089412","cross_references":{"pubmed":["35558590"],"doi":["10.1039/c8ra07013j"]}}