biostudies-literatureUnknown8(66)Ibrahim HMThe efficient, highly convenient synthesis of polysubstituted pyridine derivatives was established <i>via</i> the reaction of <i>N</i>-(benzothiazol-2-yl)-2-cyanoacetamides with an assortment of arylidene malononitriles and arylidene ethyl cyanoacetates in the presence of l-proline as an efficient organocatalyst for this type of ultrasonic-mediated Michael addition. The mechanistic pathway and factors affecting this reaction were also established. The main characteristics of this procedure are high yields, use of a cost-effective catalyst, and easy work-up and purification.RSC advances37606-37617https://www.ebi.ac.uk/biostudies/studies/S-EPMC9089412biostudies-literaturel-Proline catalyzed one-pot synthesis of polysubstituted pyridine system incorporating benzothiazole moiety <i>via</i> sustainable sonochemical approach.PMC9089412Ahmed Arafa WABehbehani HIbrahim HMfalsel-Proline catalyzed one-pot synthesis of polysubstituted pyridine system incorporating benzothiazole moiety <i>via</i> sustainable sonochemical approach.The efficient, highly convenient synthesis of polysubstituted pyridine derivatives was established <i>via</i> the reaction of <i>N</i>-(benzothiazol-2-yl)-2-cyanoacetamides with an assortment of arylidene malononitriles and arylidene ethyl cyanoacetates in the presence of l-proline as an efficient organocatalyst for this type of ultrasonic-mediated Michael addition. The mechanistic pathway and factors affecting this reaction were also established. The main characteristics of this procedure are high yields, use of a cost-effective catalyst, and easy work-up and purification.2018-01-01T00:00:00Z2018 Nov2026-06-04T17:06:53.806Z2024-12-04T00:19:58.92ZS-EPMC90894123555859010.1039/c8ra07013j