{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mencarelli L"],"funding":["NICHD NIH HHS","NIA NIH HHS","NCRR NIH HHS","NIMH NIH HHS","NINDS NIH HHS","National Institutes of Health","NIH HHS"],"pagination":["1843-1856"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9094635"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["98(10)"],"pubmed_abstract":["Dynamics within and between functional resting-state networks have a crucial role in determining both healthy and pathological brain functioning in humans. The possibility to noninvasively interact and selectively modulate the activity of networks would open to relevant applications in neuroscience. Here we tested a novel approach for multichannel, network-targeted transcranial direct current stimulation (net-tDCS), optimized to increase excitability of the sensorimotor network (SMN) while inducing cathodal inhibitory modulation over prefrontal and parietal brain regions negatively correlated with the SMN. Using an MRI-compatible multichannel transcranial electrical stimulation (tES) device, 20 healthy participants underwent real and sham tDCS while at rest in the MRI scanner. Changes in functional connectivity (FC) during and after stimulation were evaluated, looking at the intrinsic FC of the SMN and the strength of the negative connectivity between SMN and the rest of the brain. Standard, bifocal tDCS targeting left motor cortex (electrode ~C3) and right frontopolar (~Fp2) regions was tested as a control condition in a separate sample of healthy subjects to investigate network specificity of multichannel stimulation effects. Net-tDCS induced greater FC increase over the SMN compared to bifocal tDCS, during and after stimulation. Moreover, exploratory analysis of the impact of net-tDCS on negatively correlated networks showed an increase in the negative connectivity between SMN and prefrontal/parietal areas targeted by cathodal stimulation both during and after real net-tDCS. Results suggest preliminary evidence of the possibility of manipulating distributed network connectivity patterns through net-tDCS, with potential relevance for the development of cognitive enhancement and therapeutic tES solutions."],"journal":["Journal of neuroscience research"],"pubmed_title":["Impact of network-targeted multichannel transcranial direct current stimulation on intrinsic and network-to-network functional connectivity."],"pmcid":["PMC9094635"],"funding_grant_id":["R01 NS073601","R01 HD069776","UL1 RR025758","R01 AG060981-01","R21 NS085491","R01 MH117063","R21 MH099196","P01 AG031720","R01 AG060981‐01","R01 AG060981","R21 NS082870"],"pubmed_authors":["Ruffini G","Monti L","Momi D","Salvador R","Menardi A","Pascual-Leone A","Santarnecchi E","Neri F","Mencarelli L","Sprugnoli G","Rossi S","Rossi A"],"additional_accession":[]},"is_claimable":false,"name":"Impact of network-targeted multichannel transcranial direct current stimulation on intrinsic and network-to-network functional connectivity.","description":"Dynamics within and between functional resting-state networks have a crucial role in determining both healthy and pathological brain functioning in humans. The possibility to noninvasively interact and selectively modulate the activity of networks would open to relevant applications in neuroscience. Here we tested a novel approach for multichannel, network-targeted transcranial direct current stimulation (net-tDCS), optimized to increase excitability of the sensorimotor network (SMN) while inducing cathodal inhibitory modulation over prefrontal and parietal brain regions negatively correlated with the SMN. Using an MRI-compatible multichannel transcranial electrical stimulation (tES) device, 20 healthy participants underwent real and sham tDCS while at rest in the MRI scanner. Changes in functional connectivity (FC) during and after stimulation were evaluated, looking at the intrinsic FC of the SMN and the strength of the negative connectivity between SMN and the rest of the brain. Standard, bifocal tDCS targeting left motor cortex (electrode ~C3) and right frontopolar (~Fp2) regions was tested as a control condition in a separate sample of healthy subjects to investigate network specificity of multichannel stimulation effects. Net-tDCS induced greater FC increase over the SMN compared to bifocal tDCS, during and after stimulation. Moreover, exploratory analysis of the impact of net-tDCS on negatively correlated networks showed an increase in the negative connectivity between SMN and prefrontal/parietal areas targeted by cathodal stimulation both during and after real net-tDCS. Results suggest preliminary evidence of the possibility of manipulating distributed network connectivity patterns through net-tDCS, with potential relevance for the development of cognitive enhancement and therapeutic tES solutions.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Oct","modification":"2025-04-26T12:25:15.843Z","creation":"2025-04-06T13:56:48.415Z"},"accession":"S-EPMC9094635","cross_references":{"pubmed":["32686203"],"doi":["10.1002/jnr.24690"]}}