biostudies-literatureUnknown17(1)Wang DHomologous recombination deficiency (HRD) commonly occurs in breast cancer, which is the second cause of cancer death in women with a high rate of relapse and poor outcomes. Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer. Thus, we aim to develop a prognostic signature based on HRD expecting to help improve outcomes in TNBC. The Cancer Genome Atlas (TCGA)-TNBC cohort was divided into the training set and the testing set randomly. Sixteen genes were filtered from the prognostic HRD-associated genes to establish a prognostic model in the training set. Patients were divided into high-risk and low-risk groups based on the median value of the risk score. Prognosis analysis showed that the high-risk group was associated with a worse prognosis in the training Open medicine (Warsaw, Poland)882-896https://www.ebi.ac.uk/biostudies/studies/S-EPMC9096232biostudies-literatureA 16-gene signature associated with homologous recombination deficiency for prognosis prediction in patients with triple-negative breast cancer.PMC9096232He YZhao QWang DHuang HSu WShi YfalseA 16-gene signature associated with homologous recombination deficiency for prognosis prediction in patients with triple-negative breast cancer.Homologous recombination deficiency (HRD) commonly occurs in breast cancer, which is the second cause of cancer death in women with a high rate of relapse and poor outcomes. Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer. Thus, we aim to develop a prognostic signature based on HRD expecting to help improve outcomes in TNBC. The Cancer Genome Atlas (TCGA)-TNBC cohort was divided into the training set and the testing set randomly. Sixteen genes were filtered from the prognostic HRD-associated genes to establish a prognostic model in the training set. Patients were divided into high-risk and low-risk groups based on the median value of the risk score. Prognosis analysis showed that the high-risk group was associated with a worse prognosis in the training 2022-01-01T00:00:00Z20222025-04-05T16:10:58.17Z2025-02-19T02:26:16.849ZS-EPMC90962323595003310.1515/med-2022-0475