biostudies-literatureZhang XNational Natural Science Foundation of China2761https://www.ebi.ac.uk/biostudies/studies/S-EPMC9100073biostudies-literatureUnknown27(9)In order to improve the aqueous solubility and enhance the bioavailability of <i>Hyperoside</i> (Hyp), three inclusion complexes (ICs) of Hyp with 2-hydroxypropyl-β-cyclodextrin (2H-β-CD), β-cyclodextrin (β-CD), and methyl-β-cyclodextrin (M-β-CD) were prepared using the ultrasonic method. The characterization of the inclusion complexes (ICs) was achieved using Fourier-transform infrared spectroscopy (FTIR), scanning electronic microscopy (SEM), X-ray powder diffraction (XRPD), thin-layer chromatography (TLC), and ¹H nuclear magnetic resonance (¹H NMR). The effects of the ICs on the solubility and antioxidant activity of Hyp were investigated. A Job's plot revealed that the Hyp formed ICs with three kinds of cyclodextrin (CD), all at a 1:1 stoichiometric ratio. The FTIMolecules (Basel, Switzerland)Preparation and Properties of Cyclodextrin Inclusion Complexes of <i>Hyperoside</i>.PMC91000733217290131872515Li XLi YFu XZhang XChu XLiu RSu JWang XXue JZhang RfalsePreparation and Properties of Cyclodextrin Inclusion Complexes of <i>Hyperoside</i>.In order to improve the aqueous solubility and enhance the bioavailability of <i>Hyperoside</i> (Hyp), three inclusion complexes (ICs) of Hyp with 2-hydroxypropyl-β-cyclodextrin (2H-β-CD), β-cyclodextrin (β-CD), and methyl-β-cyclodextrin (M-β-CD) were prepared using the ultrasonic method. The characterization of the inclusion complexes (ICs) was achieved using Fourier-transform infrared spectroscopy (FTIR), scanning electronic microscopy (SEM), X-ray powder diffraction (XRPD), thin-layer chromatography (TLC), and ¹H nuclear magnetic resonance (¹H NMR). The effects of the ICs on the solubility and antioxidant activity of Hyp were investigated. A Job's plot revealed that the Hyp formed ICs with three kinds of cyclodextrin (CD), all at a 1:1 stoichiometric ratio. The FTI2022-01-01T00:00:00Z2022 Apr2025-04-04T22:53:23.316Z2025-02-19T00:55:54.826ZS-EPMC91000733556611110.3390/molecules27092761