{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cerezo-Cortes MI"],"funding":["MINCIENCIAS, Colombia, partially support to Patricia del Portillo and Juan Manuel Anzola","Universidad Nacional de Colombia, Facultad de Medicina, Proyecto Hermes. Partially support the Doctoral thesis of Maria Irene Cerezo","Ministerio de Ciencia, Tecnología e Inovación de Colombia, MINCIENCIAS","Consejo Nacional de Ciencia y Tecnología CONACyT, México","Ministerio de Ciencia, Tecnología e Inovación de Colombia, MINCIENCIAS."],"pagination":["5157"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9100210"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(9)"],"pubmed_abstract":["<i>Mycobacterium tuberculosis</i> (MTB) lineage 2/Beijing is associated with high virulence and drug resistance worldwide. In Colombia, the Beijing genotype has circulated since 1997, predominantly on the pacific coast, with the Beijing-Like SIT-190 being more prevalent. This genotype conforms to a drug-resistant cluster and shows a fatal outcome in patients. To better understand virulence determinants, we performed a transcriptomic analysis with a Beijing-Like SIT-190 isolate (BL-323), and Beijing-Classic SIT-1 isolate (BC-391) in progressive tuberculosis (TB) murine model. Bacterial RNA was extracted from mice lungs on days 3, 14, 28, and 60. On average, 0.6% of the total reads mapped against MTB genomes and of those, 90% against coding genes. The strains were independently associated as"],"journal":["International journal of molecular sciences"],"pubmed_title":["Close Related Drug-Resistance Beijing Isolates of <i>Mycobacterium tuberculosis</i> Reveal a Different Transcriptomic Signature in a Murine Disease Progression Model."],"pmcid":["PMC9100210"],"funding_grant_id":["CV-2013-223279","CT-80740-004-2020","53688 and 42665","CT/731-2018"],"pubmed_authors":["Del Portillo P","Murcia MI","Mata-Espinosa DA","Bini EI","Zatarain-Barron ZL","Barrios-Payan J","Hernandez-Pando R","Cerezo-Cortes MI","Ochoa-Leyva A","Rodriguez-Castillo JG","Anzola JM","Cornejo-Granados F"],"additional_accession":[]},"is_claimable":false,"name":"Close Related Drug-Resistance Beijing Isolates of <i>Mycobacterium tuberculosis</i> Reveal a Different Transcriptomic Signature in a Murine Disease Progression Model.","description":"<i>Mycobacterium tuberculosis</i> (MTB) lineage 2/Beijing is associated with high virulence and drug resistance worldwide. In Colombia, the Beijing genotype has circulated since 1997, predominantly on the pacific coast, with the Beijing-Like SIT-190 being more prevalent. This genotype conforms to a drug-resistant cluster and shows a fatal outcome in patients. To better understand virulence determinants, we performed a transcriptomic analysis with a Beijing-Like SIT-190 isolate (BL-323), and Beijing-Classic SIT-1 isolate (BC-391) in progressive tuberculosis (TB) murine model. Bacterial RNA was extracted from mice lungs on days 3, 14, 28, and 60. On average, 0.6% of the total reads mapped against MTB genomes and of those, 90% against coding genes. The strains were independently associated as","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2026-05-08T03:10:43.509Z","creation":"2024-10-16T11:36:34.923Z"},"accession":"S-EPMC9100210","cross_references":{"pubmed":["35563545"],"doi":["10.3390/ijms23095157"]}}