{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(23)"],"submitter":["Doloczki S"],"pubmed_abstract":["In this work, a series of fluorescent 2,1,3-benzothiadiazole derivatives with various <i>N</i>-substituents in the 4-position was synthesized and photophysically characterized in various solvents. Three compounds emerged as excellent fluorescent probes for imaging lipid droplets in cancer cells. A correlation between their high lipophilicity and lipid droplet specificity could be found, with log <i>P</i> ≥ 4 being characteristic for lipid droplet accumulation."],"journal":["RSC advances"],"pagination":["14544-14550"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9101220"],"repository":["biostudies-literature"],"pubmed_title":["Photophysical characterization and fluorescence cell imaging applications of 4-<i>N</i>-substituted benzothiadiazoles."],"pmcid":["PMC9101220"],"pubmed_authors":["Dyrager C","Swartling FJ","Doloczki S","Holmberg KO","Fdez Galvan I"],"additional_accession":[]},"is_claimable":false,"name":"Photophysical characterization and fluorescence cell imaging applications of 4-<i>N</i>-substituted benzothiadiazoles.","description":"In this work, a series of fluorescent 2,1,3-benzothiadiazole derivatives with various <i>N</i>-substituents in the 4-position was synthesized and photophysically characterized in various solvents. Three compounds emerged as excellent fluorescent probes for imaging lipid droplets in cancer cells. A correlation between their high lipophilicity and lipid droplet specificity could be found, with log <i>P</i> ≥ 4 being characteristic for lipid droplet accumulation.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-18T16:45:19.579Z","creation":"2024-11-12T01:37:39.61Z"},"accession":"S-EPMC9101220","cross_references":{"pubmed":["35702197"],"doi":["10.1039/d2ra01404a"]}}