biostudies-literatureUnknown12(23)Doloczki SIn this work, a series of fluorescent 2,1,3-benzothiadiazole derivatives with various <i>N</i>-substituents in the 4-position was synthesized and photophysically characterized in various solvents. Three compounds emerged as excellent fluorescent probes for imaging lipid droplets in cancer cells. A correlation between their high lipophilicity and lipid droplet specificity could be found, with log <i>P</i> ≥ 4 being characteristic for lipid droplet accumulation.RSC advances14544-14550https://www.ebi.ac.uk/biostudies/studies/S-EPMC9101220biostudies-literaturePhotophysical characterization and fluorescence cell imaging applications of 4-<i>N</i>-substituted benzothiadiazoles.PMC9101220Dyrager CSwartling FJDoloczki SHolmberg KOFdez Galvan IfalsePhotophysical characterization and fluorescence cell imaging applications of 4-<i>N</i>-substituted benzothiadiazoles.In this work, a series of fluorescent 2,1,3-benzothiadiazole derivatives with various <i>N</i>-substituents in the 4-position was synthesized and photophysically characterized in various solvents. Three compounds emerged as excellent fluorescent probes for imaging lipid droplets in cancer cells. A correlation between their high lipophilicity and lipid droplet specificity could be found, with log <i>P</i> ≥ 4 being characteristic for lipid droplet accumulation.2022-01-01T00:00:00Z2022 May2025-04-18T16:45:19.579Z2024-11-12T01:37:39.61ZS-EPMC91012203570219710.1039/d2ra01404a