{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pignatelli J"],"funding":["Biomedical Research Networking Center on Neurodegenerative Diseases","Comunidad de Madrid","Ministerio de ciencia e innovación. Agencia estatal de investigación"],"pagination":["4679"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9101627"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(9)"],"pubmed_abstract":["Uncoupling of metabolism and circadian activity is associated with an increased risk of a wide spectrum of pathologies. Recently, insulin and the closely related insulin-like growth factor I (IGF-I) were shown to entrain feeding patterns with circadian rhythms. Both hormones act centrally to modulate peripheral glucose metabolism; however, whereas central targets of insulin actions are intensely scrutinized, those mediating the actions of IGF-I remain less defined. We recently showed that IGF-I targets orexin neurons in the lateral hypothalamus, and now we evaluated whether IGF-I modulates orexin neurons to align circadian rhythms with metabolism. Mice with disrupted IGF-IR activity in orexin neurons (Firoc mice) showed sexually dimorphic alterations in daily glucose rhythms and feeding ac"],"journal":["International journal of molecular sciences"],"pubmed_title":["Insulin-like Growth Factor I Couples Metabolism with Circadian Activity through Hypothalamic Orexin Neurons."],"pmcid":["PMC9101627"],"funding_grant_id":["B2017/BMD-3700","PID2019-104376RB-I00","PIE14/00061"],"pubmed_authors":["Horrillo D","Aleman IT","Pignatelli J","de Sevilla MEF","Sperber J","Medina-Gomez G"],"additional_accession":[]},"is_claimable":false,"name":"Insulin-like Growth Factor I Couples Metabolism with Circadian Activity through Hypothalamic Orexin Neurons.","description":"Uncoupling of metabolism and circadian activity is associated with an increased risk of a wide spectrum of pathologies. Recently, insulin and the closely related insulin-like growth factor I (IGF-I) were shown to entrain feeding patterns with circadian rhythms. Both hormones act centrally to modulate peripheral glucose metabolism; however, whereas central targets of insulin actions are intensely scrutinized, those mediating the actions of IGF-I remain less defined. We recently showed that IGF-I targets orexin neurons in the lateral hypothalamus, and now we evaluated whether IGF-I modulates orexin neurons to align circadian rhythms with metabolism. Mice with disrupted IGF-IR activity in orexin neurons (Firoc mice) showed sexually dimorphic alterations in daily glucose rhythms and feeding ac","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-04T22:53:04.777Z","creation":"2025-02-19T00:55:41.143Z"},"accession":"S-EPMC9101627","cross_references":{"pubmed":["35563069"],"doi":["10.3390/ijms23094679"]}}