{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["36(9)"],"submitter":["Tan RSJ"],"pubmed_abstract":["<h4>Objectives</h4>The clinical efficacy of corticosteroids remains unclear. The primary aim of this systematic review and meta-analysis was to evaluate the use of high-dose versus low- dose corticosteroids on the mortality rate of COVID-19 patients.<h4>Design</h4>Systematic review and meta-analysis.<h4>Setting</h4>Electronic search for randomized controlled trials and observational studies (MEDLINE, EMBASE, CENTRAL).<h4>Participants</h4>Hospitalized adults ≥ 18 years old who were SARS-CoV-2 PCR positive.<h4>Interventions</h4>High-dose and low-dose corticosteroids.<h4>Measurements and main results</h4>A total of twelve studies (n=2759 patients) were included in this review. The pooled analysis demonstrated no significant difference in mortality rate between the high-dose and low-dose corti"],"journal":["Journal of cardiothoracic and vascular anesthesia"],"pagination":["3576-3586"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9101704"],"repository":["biostudies-literature"],"pubmed_title":["High-Dose versus Low-Dose Corticosteroids in COVID-19 Patients: a Systematic Review and Meta-analysis."],"pmcid":["PMC9101704"],"pubmed_authors":["Xin CE","Tan RSJ","Hasan MS","Atan R","Ng KT","Yunos NM"],"additional_accession":[]},"is_claimable":false,"name":"High-Dose versus Low-Dose Corticosteroids in COVID-19 Patients: a Systematic Review and Meta-analysis.","description":"<h4>Objectives</h4>The clinical efficacy of corticosteroids remains unclear. The primary aim of this systematic review and meta-analysis was to evaluate the use of high-dose versus low- dose corticosteroids on the mortality rate of COVID-19 patients.<h4>Design</h4>Systematic review and meta-analysis.<h4>Setting</h4>Electronic search for randomized controlled trials and observational studies (MEDLINE, EMBASE, CENTRAL).<h4>Participants</h4>Hospitalized adults ≥ 18 years old who were SARS-CoV-2 PCR positive.<h4>Interventions</h4>High-dose and low-dose corticosteroids.<h4>Measurements and main results</h4>A total of twelve studies (n=2759 patients) were included in this review. The pooled analysis demonstrated no significant difference in mortality rate between the high-dose and low-dose corti","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-04T19:52:11.302Z","creation":"2025-02-19T00:55:37.487Z"},"accession":"S-EPMC9101704","cross_references":{"pubmed":["35715291"],"doi":["10.1053/j.jvca.2022.05.011"]}}