biostudies-literatureUnknown36(9)Tan RSJ<h4>Objectives</h4>The clinical efficacy of corticosteroids remains unclear. The primary aim of this systematic review and meta-analysis was to evaluate the use of high-dose versus low- dose corticosteroids on the mortality rate of COVID-19 patients.<h4>Design</h4>Systematic review and meta-analysis.<h4>Setting</h4>Electronic search for randomized controlled trials and observational studies (MEDLINE, EMBASE, CENTRAL).<h4>Participants</h4>Hospitalized adults ≥ 18 years old who were SARS-CoV-2 PCR positive.<h4>Interventions</h4>High-dose and low-dose corticosteroids.<h4>Measurements and main results</h4>A total of twelve studies (n=2759 patients) were included in this review. The pooled analysis demonstrated no significant difference in mortality rate between the high-dose and low-dose cortiJournal of cardiothoracic and vascular anesthesia3576-3586https://www.ebi.ac.uk/biostudies/studies/S-EPMC9101704biostudies-literatureHigh-Dose versus Low-Dose Corticosteroids in COVID-19 Patients: a Systematic Review and Meta-analysis.PMC9101704Xin CETan RSJHasan MSAtan RNg KTYunos NMfalseHigh-Dose versus Low-Dose Corticosteroids in COVID-19 Patients: a Systematic Review and Meta-analysis.<h4>Objectives</h4>The clinical efficacy of corticosteroids remains unclear. The primary aim of this systematic review and meta-analysis was to evaluate the use of high-dose versus low- dose corticosteroids on the mortality rate of COVID-19 patients.<h4>Design</h4>Systematic review and meta-analysis.<h4>Setting</h4>Electronic search for randomized controlled trials and observational studies (MEDLINE, EMBASE, CENTRAL).<h4>Participants</h4>Hospitalized adults ≥ 18 years old who were SARS-CoV-2 PCR positive.<h4>Interventions</h4>High-dose and low-dose corticosteroids.<h4>Measurements and main results</h4>A total of twelve studies (n=2759 patients) were included in this review. The pooled analysis demonstrated no significant difference in mortality rate between the high-dose and low-dose corti2022-01-01T00:00:00Z2022 Sep2025-04-04T19:52:11.302Z2025-02-19T00:55:37.487ZS-EPMC91017043571529110.1053/j.jvca.2022.05.011