{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Abalos P"],"funding":["SAG-FAVET collaboration and transfer agreement"],"pagination":["1083"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9102018"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(9)"],"pubmed_abstract":["Bovine tuberculosis (bTB) is a zoonotic disease caused mainly by <i>Mycobacterium bovis</i>, which is associated with major economic losses for milk and meat producers. The objective of this trial was to assess the efficacy of the BCG Russia strain in a cohort study performed under field conditions, with the vaccination of calves in seven dairy farms from a high prevalence area in central Chile. The trial was performed with 501 animals, subcutaneously vaccinated with 2-8 × 10<sup>5</sup> colony-forming units of BCG, whilst 441 matched control animals received a saline placebo. Peripheral blood was collected at 6, 12 and 18 months post-vaccination, and infection status was determined using the IFNγ release assay in conjunction with the DIVA (Detecting Infected amongst Vaccinated Animals) antigens ESAT-6, CFP-10 and Rv3615c. The BCG vaccine showed a low but significant level of protection of 22.4% (95% CI 4.0 to 36.4) at the end of the trial. However, diverse levels of protection and a variable duration of immunity were observed between trial herds. This diverse outcome could be influenced by the general health condition of calves and their exposition to non-tuberculous mycobacteria. These results suggest that BCG vaccination of dairy calves in a natural transmission setting confers variable protection to animals against bTB in a high prevalence area."],"journal":["Animals : an open access journal from MDPI"],"pubmed_title":["Vaccination of Calves with the <i>Mycobacterium bovis</i> BCG Strain Induces Protection against Bovine Tuberculosis in Dairy Herds under a Natural Transmission Setting."],"pmcid":["PMC9102018"],"funding_grant_id":["No number"],"pubmed_authors":["Sanchez N","Retamal P","Saadi K","Vordermeier M","Wistuba M","Alegria-Moran R","Ortega C","Perez de Val B","Benavides MB","Abalos P","Valdivieso N"],"additional_accession":[]},"is_claimable":false,"name":"Vaccination of Calves with the <i>Mycobacterium bovis</i> BCG Strain Induces Protection against Bovine Tuberculosis in Dairy Herds under a Natural Transmission Setting.","description":"Bovine tuberculosis (bTB) is a zoonotic disease caused mainly by <i>Mycobacterium bovis</i>, which is associated with major economic losses for milk and meat producers. The objective of this trial was to assess the efficacy of the BCG Russia strain in a cohort study performed under field conditions, with the vaccination of calves in seven dairy farms from a high prevalence area in central Chile. The trial was performed with 501 animals, subcutaneously vaccinated with 2-8 × 10<sup>5</sup> colony-forming units of BCG, whilst 441 matched control animals received a saline placebo. Peripheral blood was collected at 6, 12 and 18 months post-vaccination, and infection status was determined using the IFNγ release assay in conjunction with the DIVA (Detecting Infected amongst Vaccinated Animals) antigens ESAT-6, CFP-10 and Rv3615c. The BCG vaccine showed a low but significant level of protection of 22.4% (95% CI 4.0 to 36.4) at the end of the trial. However, diverse levels of protection and a variable duration of immunity were observed between trial herds. This diverse outcome could be influenced by the general health condition of calves and their exposition to non-tuberculous mycobacteria. These results suggest that BCG vaccination of dairy calves in a natural transmission setting confers variable protection to animals against bTB in a high prevalence area.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-04T22:53:43.609Z","creation":"2025-02-19T00:56:07.33Z"},"accession":"S-EPMC9102018","cross_references":{"pubmed":["35565515"],"doi":["10.3390/ani12091083"]}}