{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mietelska-Porowska A"],"funding":["National Science Center"],"pagination":["4744"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9102094"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(9)"],"pubmed_abstract":["The term Western diet (WD) describes the consumption of large amounts of highly processed foods, rich in simple sugars and saturated fats. Long-term WD feeding leads to insulin resistance, postulated as a risk factor for Alzheimer's disease (AD). AD is the main cause of progressive dementia characterized by the deposition of amyloid-β (Aβ) plaques and neurofibrillary tangles consisting of the hyperphosphorylated tau (p-Tau) protein in the brain, starting from the entorhinal cortex and the hippocampus. In this study, we report that WD-derived impairment in insulin signaling induces tau and Aβ brain pathology in wild-type C57BL/6 mice, and that the entorhinal cortex is more sensitive than the hippocampus to the impairment of brain insulin signaling. In the brain areas developing WD-induced i"],"journal":["International journal of molecular sciences"],"pubmed_title":["Induction of Brain Insulin Resistance and Alzheimer's Molecular Changes by Western Diet."],"pmcid":["PMC9102094"],"funding_grant_id":["No. UMO-2014/15/D/NZ4/04361"],"pubmed_authors":["Want A","Domanska J","Wojda U","Mietelska-Porowska A","Wieckowska-Gacek A","Chutoranski D","Koperski M"],"additional_accession":[]},"is_claimable":false,"name":"Induction of Brain Insulin Resistance and Alzheimer's Molecular Changes by Western Diet.","description":"The term Western diet (WD) describes the consumption of large amounts of highly processed foods, rich in simple sugars and saturated fats. Long-term WD feeding leads to insulin resistance, postulated as a risk factor for Alzheimer's disease (AD). AD is the main cause of progressive dementia characterized by the deposition of amyloid-β (Aβ) plaques and neurofibrillary tangles consisting of the hyperphosphorylated tau (p-Tau) protein in the brain, starting from the entorhinal cortex and the hippocampus. In this study, we report that WD-derived impairment in insulin signaling induces tau and Aβ brain pathology in wild-type C57BL/6 mice, and that the entorhinal cortex is more sensitive than the hippocampus to the impairment of brain insulin signaling. In the brain areas developing WD-induced i","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-18T14:31:31.142Z","creation":"2025-02-19T00:56:24.304Z"},"accession":"S-EPMC9102094","cross_references":{"pubmed":["35563135"],"doi":["10.3390/ijms23094744"]}}