{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shurpik DN"],"funding":["Russian Science Foundation"],"pagination":["1604"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9102331"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(9)"],"pubmed_abstract":["Polymer self-healing films containing fragments of pillar[5]arene were obtained for the first time using thiol/disulfide redox cross-linking. These films were characterized by thermogravimetric analysis and differential scanning calorimetry, FTIR spectroscopy, and electron microscopy. The films demonstrated the ability to self-heal through the action of atmospheric oxygen. Using UV-vis, 2D 1H-1H NOESY, and DOSY NMR spectroscopy, the pillar[5]arene was shown to form complexes with the antimicrobial drug moxifloxacin in a 2:1 composition (logK11 = 2.14 and logK12 = 6.20). Films containing moxifloxacin effectively reduced <i>Staphylococcus aureus</i> and <i>Klebsiella pneumoniae</i> biofilms formation on adhesive surfaces."],"journal":["Nanomaterials (Basel, Switzerland)"],"pubmed_title":["Self-Healing Thiolated Pillar[5]arene Films Containing Moxifloxacin Suppress the Development of Bacterial Biofilms."],"pmcid":["PMC9102331"],"funding_grant_id":["20-73-00161"],"pubmed_authors":["Gorodov VV","Murzakhanov FF","Stoikov II","Islamov DR","Mostovaya OA","Nazmutdinova VA","Gafurov MR","Gerasimov AV","Shurpik DN","Zelenikhin PV","Subakaeva EV","Aleksandrova YI","Tazieva RE","Cragg PJ","Sokolova EA"],"additional_accession":[]},"is_claimable":false,"name":"Self-Healing Thiolated Pillar[5]arene Films Containing Moxifloxacin Suppress the Development of Bacterial Biofilms.","description":"Polymer self-healing films containing fragments of pillar[5]arene were obtained for the first time using thiol/disulfide redox cross-linking. These films were characterized by thermogravimetric analysis and differential scanning calorimetry, FTIR spectroscopy, and electron microscopy. The films demonstrated the ability to self-heal through the action of atmospheric oxygen. Using UV-vis, 2D 1H-1H NOESY, and DOSY NMR spectroscopy, the pillar[5]arene was shown to form complexes with the antimicrobial drug moxifloxacin in a 2:1 composition (logK11 = 2.14 and logK12 = 6.20). Films containing moxifloxacin effectively reduced <i>Staphylococcus aureus</i> and <i>Klebsiella pneumoniae</i> biofilms formation on adhesive surfaces.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-18T14:31:33.396Z","creation":"2025-02-19T00:56:29.714Z"},"accession":"S-EPMC9102331","cross_references":{"pubmed":["35564312"],"doi":["10.3390/nano12091604"]}}