biostudies-literatureShurpik DNRussian Science Foundation1604https://www.ebi.ac.uk/biostudies/studies/S-EPMC9102331biostudies-literatureUnknown12(9)Polymer self-healing films containing fragments of pillar[5]arene were obtained for the first time using thiol/disulfide redox cross-linking. These films were characterized by thermogravimetric analysis and differential scanning calorimetry, FTIR spectroscopy, and electron microscopy. The films demonstrated the ability to self-heal through the action of atmospheric oxygen. Using UV-vis, 2D 1H-1H NOESY, and DOSY NMR spectroscopy, the pillar[5]arene was shown to form complexes with the antimicrobial drug moxifloxacin in a 2:1 composition (logK11 = 2.14 and logK12 = 6.20). Films containing moxifloxacin effectively reduced <i>Staphylococcus aureus</i> and <i>Klebsiella pneumoniae</i> biofilms formation on adhesive surfaces.Nanomaterials (Basel, Switzerland)Self-Healing Thiolated Pillar[5]arene Films Containing Moxifloxacin Suppress the Development of Bacterial Biofilms.PMC910233120-73-00161Gorodov VVMurzakhanov FFStoikov IIIslamov DRMostovaya OANazmutdinova VAGafurov MRGerasimov AVShurpik DNZelenikhin PVSubakaeva EVAleksandrova YITazieva RECragg PJSokolova EAfalseSelf-Healing Thiolated Pillar[5]arene Films Containing Moxifloxacin Suppress the Development of Bacterial Biofilms.Polymer self-healing films containing fragments of pillar[5]arene were obtained for the first time using thiol/disulfide redox cross-linking. These films were characterized by thermogravimetric analysis and differential scanning calorimetry, FTIR spectroscopy, and electron microscopy. The films demonstrated the ability to self-heal through the action of atmospheric oxygen. Using UV-vis, 2D 1H-1H NOESY, and DOSY NMR spectroscopy, the pillar[5]arene was shown to form complexes with the antimicrobial drug moxifloxacin in a 2:1 composition (logK11 = 2.14 and logK12 = 6.20). Films containing moxifloxacin effectively reduced <i>Staphylococcus aureus</i> and <i>Klebsiella pneumoniae</i> biofilms formation on adhesive surfaces.2022-01-01T00:00:00Z2022 May2025-04-18T14:31:33.396Z2025-02-19T00:56:29.714ZS-EPMC91023313556431210.3390/nano12091604