biostudies-literatureTookes HENIDA NIH HHSNIAID NIH HHSNIMH NIH HHSNational Cancer InstituteNCI NIH HHSNational Institute of Mental HealthNational Institutes of HealthNational Institute on Drug AbuseMiami Center for Aids Research109124https://www.ebi.ac.uk/biostudies/studies/S-EPMC9102418biostudies-literatureUnknown229(Pt A)<h4>Background</h4>People who inject drugs (PWID) have been a marginalized and a stigmatized population since the beginning of the AIDS epidemic and have not experienced the same life-changing benefits of antiretroviral therapy as others. Tele-Harm Reduction (THR) is a telehealth-enhanced, harm reduction intervention, delivered within a trusted SSP venue. It aims to facilitate initiation of care and achieve rapid HIV viral suppression among PWID living with HIV.<h4>Methods</h4>In this mixed-methods study, we employed the Practical, Robust, Implementation and Sustainability Model (PRISM) implementation science framework to identify multilevel barriers and facilitators to implementing the THR intervention. Focus groups (n = 2, 16 participants), stakeholder interviews (n = 7) and in-depth intDrug and alcohol dependenceAcceptability, feasibility, and pilot results of the tele-harm reduction intervention for rapid initiation of antiretrovirals among people who inject drugs.PMC9102418DP2 DA053720P30 AI073961P30CA240139P30AI073961P30 CA2401391 DP2 DA053720–013P30MH116867–01A1S1R01 DA045713P30 MH116867UG1 DA013720Bartholomew TSKolber MASternberg CForrest DWBoyd DRodriguez AMooss AMetsch LRSerota DPSuarez EGinoza MTookes HEEkowo EFeaster DJfalseAcceptability, feasibility, and pilot results of the tele-harm reduction intervention for rapid initiation of antiretrovirals among people who inject drugs.<h4>Background</h4>People who inject drugs (PWID) have been a marginalized and a stigmatized population since the beginning of the AIDS epidemic and have not experienced the same life-changing benefits of antiretroviral therapy as others. Tele-Harm Reduction (THR) is a telehealth-enhanced, harm reduction intervention, delivered within a trusted SSP venue. It aims to facilitate initiation of care and achieve rapid HIV viral suppression among PWID living with HIV.<h4>Methods</h4>In this mixed-methods study, we employed the Practical, Robust, Implementation and Sustainability Model (PRISM) implementation science framework to identify multilevel barriers and facilitators to implementing the THR intervention. Focus groups (n = 2, 16 participants), stakeholder interviews (n = 7) and in-depth int2021-01-01T00:00:00Z2021 Dec2026-06-04T04:41:09.034Z2025-04-04T19:37:50.968ZS-EPMC91024183478109610.1016/j.drugalcdep.2021.109124