{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu T"],"funding":["the National Key Research and Development Program of China","the Peking University Medicine Fund","The National Natural Science Foundation of China","Peking University Clinical + X"],"pagination":["4825"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9102452"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(9)"],"pubmed_abstract":["Alcohol liver disease (ALD) is characterized by intestinal barrier disruption and gut dysbiosis. Dysfunction of E74-like ETS transcription factor 4 (ELF4) leads to colitis. We aimed to test the hypothesis that intestinal ELF4 plays a critical role in maintaining the normal function of intestinal barrier and gut homeostasis in a mouse model of ALD. Intestinal ELF4 deficiency resulted in dysfunction of the intestinal barrier. <i>Elf4<sup>-/-</sup></i> mice exhibited gut microbiota (GM) dysbiosis with the characteristic of a larger proportion of Proteobacteria. The LPS increased in <i>Elf4<sup>-/-</sup></i> mice and was the most important differential metabolite between <i>Elf4<sup>-/-</sup></i> mice and WT mice. Alcohol exposure increased liver-to-body weight ratio, and hepatic inflammation "],"journal":["International journal of molecular sciences"],"pubmed_title":["Intestinal ELF4 Deletion Exacerbates Alcoholic Liver Disease by Disrupting Gut Homeostasis."],"pmcid":["PMC9102452"],"funding_grant_id":["2020YFA0707800; 2016YFA0500300","PKU2020LCXQ009","31570891; 31872736; 32022028 and 81991505"],"pubmed_authors":["Xie Y","Yang L","Zhang Z","Liu T","Yu H","You F"],"additional_accession":[]},"is_claimable":false,"name":"Intestinal ELF4 Deletion Exacerbates Alcoholic Liver Disease by Disrupting Gut Homeostasis.","description":"Alcohol liver disease (ALD) is characterized by intestinal barrier disruption and gut dysbiosis. Dysfunction of E74-like ETS transcription factor 4 (ELF4) leads to colitis. We aimed to test the hypothesis that intestinal ELF4 plays a critical role in maintaining the normal function of intestinal barrier and gut homeostasis in a mouse model of ALD. Intestinal ELF4 deficiency resulted in dysfunction of the intestinal barrier. <i>Elf4<sup>-/-</sup></i> mice exhibited gut microbiota (GM) dysbiosis with the characteristic of a larger proportion of Proteobacteria. The LPS increased in <i>Elf4<sup>-/-</sup></i> mice and was the most important differential metabolite between <i>Elf4<sup>-/-</sup></i> mice and WT mice. Alcohol exposure increased liver-to-body weight ratio, and hepatic inflammation ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-04T22:53:21.291Z","creation":"2025-02-19T00:55:56.746Z"},"accession":"S-EPMC9102452","cross_references":{"pubmed":["35563234"],"doi":["10.3390/ijms23094825"]}}