biostudies-literatureLiu Tthe National Key Research and Development Program of Chinathe Peking University Medicine FundThe National Natural Science Foundation of ChinaPeking University Clinical + X4825https://www.ebi.ac.uk/biostudies/studies/S-EPMC9102452biostudies-literatureUnknown23(9)Alcohol liver disease (ALD) is characterized by intestinal barrier disruption and gut dysbiosis. Dysfunction of E74-like ETS transcription factor 4 (ELF4) leads to colitis. We aimed to test the hypothesis that intestinal ELF4 plays a critical role in maintaining the normal function of intestinal barrier and gut homeostasis in a mouse model of ALD. Intestinal ELF4 deficiency resulted in dysfunction of the intestinal barrier. <i>Elf4^-/-</i> mice exhibited gut microbiota (GM) dysbiosis with the characteristic of a larger proportion of Proteobacteria. The LPS increased in <i>Elf4^-/-</i> mice and was the most important differential metabolite between <i>Elf4^-/-</i> mice and WT mice. Alcohol exposure increased liver-to-body weight ratio, and hepatic inflammation International journal of molecular sciencesIntestinal ELF4 Deletion Exacerbates Alcoholic Liver Disease by Disrupting Gut Homeostasis.PMC91024522020YFA0707800; 2016YFA0500300PKU2020LCXQ00931570891; 31872736; 32022028 and 81991505Xie YYang LZhang ZLiu TYu HYou FfalseIntestinal ELF4 Deletion Exacerbates Alcoholic Liver Disease by Disrupting Gut Homeostasis.Alcohol liver disease (ALD) is characterized by intestinal barrier disruption and gut dysbiosis. Dysfunction of E74-like ETS transcription factor 4 (ELF4) leads to colitis. We aimed to test the hypothesis that intestinal ELF4 plays a critical role in maintaining the normal function of intestinal barrier and gut homeostasis in a mouse model of ALD. Intestinal ELF4 deficiency resulted in dysfunction of the intestinal barrier. <i>Elf4^-/-</i> mice exhibited gut microbiota (GM) dysbiosis with the characteristic of a larger proportion of Proteobacteria. The LPS increased in <i>Elf4^-/-</i> mice and was the most important differential metabolite between <i>Elf4^-/-</i> mice and WT mice. Alcohol exposure increased liver-to-body weight ratio, and hepatic inflammation 2022-01-01T00:00:00Z2022 Apr2025-04-04T22:53:21.291Z2025-02-19T00:55:56.746ZS-EPMC91024523556323410.3390/ijms23094825