{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gomez-Alonso IS"],"funding":["Instituto Politécnico Nacional"],"pagination":["4992"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9102557"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(9)"],"pubmed_abstract":["Neutrophils play a crucial role in eliminating bacteria that invade the human body; however, cathepsin G can induce biofilm formation in a non-biofilm-forming Staphylococcus epidermidis 1457 strain, suggesting that neutrophil proteases may be involved in biofilm formation. Cathepsin G, cathepsin B, proteinase-3, and metalloproteinase-9 (MMP-9) from neutrophils were tested on the biofilm induction in commensal (skin isolated) and clinical non-biofilm-forming S. epidermidis isolates. From 81 isolates, 53 (74%) were aap+, icaA−, icaD− genotype, and without the capacity of biofilm formation under conditions of 1% glucose, 4% ethanol or 4% NaCl, but these 53 non-biofilm-forming isolates induced biofilm by the use of different neutrophil proteases. Of these, 62.3% induced biofilm with proteinase"],"journal":["International journal of molecular sciences"],"pubmed_title":["Low Concentration of the Neutrophil Proteases Cathepsin G, Cathepsin B, Proteinase-3 and Metalloproteinase-9 Induce Biofilm Formation in Non-Biofilm-Forming <i>Staphylococcus epidermidis</i> Isolates."],"pmcid":["PMC9102557"],"funding_grant_id":["20221193SIP","20221352SIP"],"pubmed_authors":["Herrera MT","Sanchez-Torres L","Martinez-Garcia S","Betanzos-Cabrera G","Cancino-Diaz ME","Cancino J","Cancino-Diaz JC","Rodriguez-Martinez S","Juarez E","Gomez-Alonso IS","Sarabia-Leon MC","Gomez-Chavez F"],"additional_accession":[]},"is_claimable":false,"name":"Low Concentration of the Neutrophil Proteases Cathepsin G, Cathepsin B, Proteinase-3 and Metalloproteinase-9 Induce Biofilm Formation in Non-Biofilm-Forming <i>Staphylococcus epidermidis</i> Isolates.","description":"Neutrophils play a crucial role in eliminating bacteria that invade the human body; however, cathepsin G can induce biofilm formation in a non-biofilm-forming Staphylococcus epidermidis 1457 strain, suggesting that neutrophil proteases may be involved in biofilm formation. Cathepsin G, cathepsin B, proteinase-3, and metalloproteinase-9 (MMP-9) from neutrophils were tested on the biofilm induction in commensal (skin isolated) and clinical non-biofilm-forming S. epidermidis isolates. From 81 isolates, 53 (74%) were aap+, icaA−, icaD− genotype, and without the capacity of biofilm formation under conditions of 1% glucose, 4% ethanol or 4% NaCl, but these 53 non-biofilm-forming isolates induced biofilm by the use of different neutrophil proteases. Of these, 62.3% induced biofilm with proteinase","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-08-17T03:06:08.487Z","creation":"2025-04-04T19:40:52.958Z"},"accession":"S-EPMC9102557","cross_references":{"pubmed":["35563384"],"doi":["10.3390/ijms23094992"]}}