{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sojan JM"],"funding":["European Union","Belgian Space Agency PRODEX","European Space Agency (ESA)"],"pagination":["4748"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9102566"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(9)"],"pubmed_abstract":["Zebrafish larvae, especially gene-specific mutants and transgenic lines, are increasingly used to study vertebrate skeletal development and human pathologies such as osteoporosis, osteopetrosis and osteoarthritis. Probiotics have been recognized in recent years as a prophylactic treatment for various bone health issues in humans. Here, we present two new zebrafish transgenic lines containing the coding sequences for fluorescent proteins inserted into the endogenous genes for <i>sp7</i> and <i>col10a1a</i> with larvae displaying fluorescence in developing osteoblasts and the bone extracellular matrix (mineralized or non-mineralized), respectively. Furthermore, we use these transgenic lines to show that exposure to two different probiotics, <i>Bacillus subtilis</i> and <i>Lactococcus lactis<"],"journal":["International journal of molecular sciences"],"pubmed_title":["Probiotics Enhance Bone Growth and Rescue BMP Inhibition: New Transgenic Zebrafish Lines to Study Bone Health."],"pmcid":["PMC9102566"],"funding_grant_id":["BioMedAqu","Fish in Space"],"pubmed_authors":["Muller M","Carnevali O","Sojan JM","Renn J","Raman R"],"additional_accession":[]},"is_claimable":false,"name":"Probiotics Enhance Bone Growth and Rescue BMP Inhibition: New Transgenic Zebrafish Lines to Study Bone Health.","description":"Zebrafish larvae, especially gene-specific mutants and transgenic lines, are increasingly used to study vertebrate skeletal development and human pathologies such as osteoporosis, osteopetrosis and osteoarthritis. Probiotics have been recognized in recent years as a prophylactic treatment for various bone health issues in humans. Here, we present two new zebrafish transgenic lines containing the coding sequences for fluorescent proteins inserted into the endogenous genes for <i>sp7</i> and <i>col10a1a</i> with larvae displaying fluorescence in developing osteoblasts and the bone extracellular matrix (mineralized or non-mineralized), respectively. Furthermore, we use these transgenic lines to show that exposure to two different probiotics, <i>Bacillus subtilis</i> and <i>Lactococcus lactis<","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2026-05-06T03:16:56.072Z","creation":"2024-11-20T02:08:50.103Z"},"accession":"S-EPMC9102566","cross_references":{"pubmed":["35563140"],"doi":["10.3390/ijms23094748"]}}