{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Eyileten C"],"funding":["National Science Center"],"pagination":["4530"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9102701"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(9)"],"pubmed_abstract":["Background
Increased inflammation activates blood coagulation system, higher platelet activation plays a key role in the pathophysiology of ischemic stroke (IS). During platelet activation and aggregation process, platelets may cause increased release of several proinflammatory, and prothrombotic mediators, including microRNAs (miRNAs) and extracellular vesicles (EVs). In the current study we aimed to assess circulating miRNAs profile related to platelet function and inflammation and circulating EVs from platelets, leukocytes, and endothelial cells to analyse their diagnostic and predictive utility in patients with acute IS.Methods
The study population consisted of 28 patients with the diagnosis of the acute IS. The control group consisted of 35 age- and gender-matched pati"],"journal":["International journal of molecular sciences"],"pubmed_title":["Diagnostic Performance of Circulating miRNAs and Extracellular Vesicles in Acute Ischemic Stroke."],"pmcid":["PMC9102701"],"funding_grant_id":["2017/25/N/NZ5/00545"],"pubmed_authors":["van der Pol E","Postula M","Gajewska M","Shahzadi A","Jakubik D","Gasecka A","De Rosa S","Siwik D","Kurkowska-Jastrzebska I","Mirowska-Guzel D","Czlonkowska A","Eyileten C"],"additional_accession":[]},"is_claimable":false,"name":"Diagnostic Performance of Circulating miRNAs and Extracellular Vesicles in Acute Ischemic Stroke.","description":"Background
Increased inflammation activates blood coagulation system, higher platelet activation plays a key role in the pathophysiology of ischemic stroke (IS). During platelet activation and aggregation process, platelets may cause increased release of several proinflammatory, and prothrombotic mediators, including microRNAs (miRNAs) and extracellular vesicles (EVs). In the current study we aimed to assess circulating miRNAs profile related to platelet function and inflammation and circulating EVs from platelets, leukocytes, and endothelial cells to analyse their diagnostic and predictive utility in patients with acute IS.Methods
The study population consisted of 28 patients with the diagnosis of the acute IS. The control group consisted of 35 age- and gender-matched pati","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-04T22:53:17.683Z","creation":"2025-02-19T00:55:58.536Z"},"accession":"S-EPMC9102701","cross_references":{"pubmed":["35562921"],"doi":["10.3390/ijms23094530"]}}