{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Khamphukdee C"],"funding":["the Young Researcher Development Project of Khon Kaen University and partially supported by the Thailand Research Fund"],"pagination":["3014"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9103351"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(9)"],"pubmed_abstract":["The present study describes investigation of the effects of the bark resin extract of <i>Garcinia nigrolineata</i> (Clusiaceae) on the cognitive function and the induction of oxidative stress in both frontal cortex and hippocampus by unpredictable chronic mild stress (UCMS). By using behavioral mouse models, i.e., the Y-maze test, the Novel Object Recognition Test (NORT), and the Morris Water Maze Test (MWMT), it was found that the negative impact of repeated mild stress-induced learning and memory deficit through brain oxidative stress in the UCMS mice was reversed by treatment with the bark resin extract <i>G. nigrolineata</i>. Moreover, the prenylated xanthones <i>viz.</i> cowagarcinone C, cowaxanthone, α-mangostin, cowaxanthone B, cowanin, fuscaxanthone A, fuscaxanthone B, xanthochymus"],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Effects of the Bark Resin Extract of <i>Garcinia nigrolineata</i> on Chronic Stress-Induced Memory Deficit in Mice Model and the In Vitro Monoamine Oxidases and β-Amyloid Aggregation Inhibitory Activities of Its Prenylated Xanthone Constituents."],"pmcid":["PMC9103351"],"funding_grant_id":["RDG5520030"],"pubmed_authors":["Kijjoa A","Boonyarat C","Khamphukdee C","Silva AMS","Chulikhit Y","Turkmani I","Sekeroglu N","Chotritthirong Y","Monthakantirat O"],"additional_accession":[]},"is_claimable":false,"name":"Effects of the Bark Resin Extract of <i>Garcinia nigrolineata</i> on Chronic Stress-Induced Memory Deficit in Mice Model and the In Vitro Monoamine Oxidases and β-Amyloid Aggregation Inhibitory Activities of Its Prenylated Xanthone Constituents.","description":"The present study describes investigation of the effects of the bark resin extract of <i>Garcinia nigrolineata</i> (Clusiaceae) on the cognitive function and the induction of oxidative stress in both frontal cortex and hippocampus by unpredictable chronic mild stress (UCMS). By using behavioral mouse models, i.e., the Y-maze test, the Novel Object Recognition Test (NORT), and the Morris Water Maze Test (MWMT), it was found that the negative impact of repeated mild stress-induced learning and memory deficit through brain oxidative stress in the UCMS mice was reversed by treatment with the bark resin extract <i>G. nigrolineata</i>. Moreover, the prenylated xanthones <i>viz.</i> cowagarcinone C, cowaxanthone, α-mangostin, cowaxanthone B, cowanin, fuscaxanthone A, fuscaxanthone B, xanthochymus","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-04T20:35:29.639Z","creation":"2025-02-19T03:41:55.697Z"},"accession":"S-EPMC9103351","cross_references":{"pubmed":["35566362"],"doi":["10.3390/molecules27093014"]}}