biostudies-literatureKhamphukdee Cthe Young Researcher Development Project of Khon Kaen University and partially supported by the Thailand Research Fund3014https://www.ebi.ac.uk/biostudies/studies/S-EPMC9103351biostudies-literatureUnknown27(9)The present study describes investigation of the effects of the bark resin extract of <i>Garcinia nigrolineata</i> (Clusiaceae) on the cognitive function and the induction of oxidative stress in both frontal cortex and hippocampus by unpredictable chronic mild stress (UCMS). By using behavioral mouse models, i.e., the Y-maze test, the Novel Object Recognition Test (NORT), and the Morris Water Maze Test (MWMT), it was found that the negative impact of repeated mild stress-induced learning and memory deficit through brain oxidative stress in the UCMS mice was reversed by treatment with the bark resin extract <i>G. nigrolineata</i>. Moreover, the prenylated xanthones <i>viz.</i> cowagarcinone C, cowaxanthone, α-mangostin, cowaxanthone B, cowanin, fuscaxanthone A, fuscaxanthone B, xanthochymusMolecules (Basel, Switzerland)Effects of the Bark Resin Extract of <i>Garcinia nigrolineata</i> on Chronic Stress-Induced Memory Deficit in Mice Model and the In Vitro Monoamine Oxidases and β-Amyloid Aggregation Inhibitory Activities of Its Prenylated Xanthone Constituents.PMC9103351RDG5520030Kijjoa ABoonyarat CKhamphukdee CSilva AMSChulikhit YTurkmani ISekeroglu NChotritthirong YMonthakantirat OfalseEffects of the Bark Resin Extract of <i>Garcinia nigrolineata</i> on Chronic Stress-Induced Memory Deficit in Mice Model and the In Vitro Monoamine Oxidases and β-Amyloid Aggregation Inhibitory Activities of Its Prenylated Xanthone Constituents.The present study describes investigation of the effects of the bark resin extract of <i>Garcinia nigrolineata</i> (Clusiaceae) on the cognitive function and the induction of oxidative stress in both frontal cortex and hippocampus by unpredictable chronic mild stress (UCMS). By using behavioral mouse models, i.e., the Y-maze test, the Novel Object Recognition Test (NORT), and the Morris Water Maze Test (MWMT), it was found that the negative impact of repeated mild stress-induced learning and memory deficit through brain oxidative stress in the UCMS mice was reversed by treatment with the bark resin extract <i>G. nigrolineata</i>. Moreover, the prenylated xanthones <i>viz.</i> cowagarcinone C, cowaxanthone, α-mangostin, cowaxanthone B, cowanin, fuscaxanthone A, fuscaxanthone B, xanthochymus2022-01-01T00:00:00Z2022 May2025-04-04T20:35:29.639Z2025-02-19T03:41:55.697ZS-EPMC91033513556636210.3390/molecules27093014