{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sahu S"],"funding":["University Grants Commission"],"pagination":["2859"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9103770"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(9)"],"pubmed_abstract":["Optical chemosensors caused a revolution in the field of sensing due to their high specificity, sensitivity, and fast detection features. Imidazole derivatives have offered promising features in the literature as they bear suitable donor/acceptor groups for the selective analytes in the skeleton. In this work, an isoindole-imidazole containing a Schiff base chemosensor (1-{3-[(2-Diethylamino-ethylimino)-methyl]-2-hydroxy-5-methyl-phenyl}-2H-imidazo[5,1-a]isoindole-3,5-dione) was designed and synthesized. The complete sensing phenomena have been investigated by means of UV-Vis, fluorescence, lifetime measurement, FT-IR, NMR and ESI-MS spectroscopic techniques. The optical properties of the synthesized ligand were investigated in 3:7 HEPES buffer:DMSO medium and found to be highly selective and sensitive toward Zn<sup>2+</sup> ion through a fluorescence turn-on response with detection limit of 0.073 μm. Furthermore, this response is effective in gel form also. The competition studies reveal that the response of the probe for Zn<sup>2+</sup> ion is unaffected by other relevant metal ions. The stoichiometric binding study was performed utilizing Job's method which indicated a 1:1 sensor-Zn<sup>2+</sup> ensemble. Computational calculations were performed to pinpoint the mechanism of sensing."],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Turn on Fluorescence Sensing of Zn<sup>2+</sup> Based on Fused Isoindole-Imidazole Scaffold."],"pmcid":["PMC9103770"],"funding_grant_id":["F1‒17.1/2017‒18/RGNF‒2017‒18‒SC‒WES‒37660/(SA‒III/Website)"],"pubmed_authors":["Cerezo J","Goswami S","Sahu S","Bag R","Ceron-Carrasco JP","Sikdar Y"],"additional_accession":[]},"is_claimable":false,"name":"Turn on Fluorescence Sensing of Zn<sup>2+</sup> Based on Fused Isoindole-Imidazole Scaffold.","description":"Optical chemosensors caused a revolution in the field of sensing due to their high specificity, sensitivity, and fast detection features. Imidazole derivatives have offered promising features in the literature as they bear suitable donor/acceptor groups for the selective analytes in the skeleton. In this work, an isoindole-imidazole containing a Schiff base chemosensor (1-{3-[(2-Diethylamino-ethylimino)-methyl]-2-hydroxy-5-methyl-phenyl}-2H-imidazo[5,1-a]isoindole-3,5-dione) was designed and synthesized. The complete sensing phenomena have been investigated by means of UV-Vis, fluorescence, lifetime measurement, FT-IR, NMR and ESI-MS spectroscopic techniques. The optical properties of the synthesized ligand were investigated in 3:7 HEPES buffer:DMSO medium and found to be highly selective and sensitive toward Zn<sup>2+</sup> ion through a fluorescence turn-on response with detection limit of 0.073 μm. Furthermore, this response is effective in gel form also. The competition studies reveal that the response of the probe for Zn<sup>2+</sup> ion is unaffected by other relevant metal ions. The stoichiometric binding study was performed utilizing Job's method which indicated a 1:1 sensor-Zn<sup>2+</sup> ensemble. Computational calculations were performed to pinpoint the mechanism of sensing.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-18T17:07:22.833Z","creation":"2025-02-19T00:56:20.027Z"},"accession":"S-EPMC9103770","cross_references":{"pubmed":["35566211"],"doi":["10.3390/molecules27092859"]}}