{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Haam CE"],"funding":["Myoung-Sun Kim Memorial Foundation"],"pagination":["2711"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9104054"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(9)"],"pubmed_abstract":["<h4>Background</h4><i>Alpinia officinarum</i> (<i>A. officinarum</i>) is known to exhibit a beneficial effect for anti-inflammatory, anti-oxidant, and anti-hyperlipidemic effects. However, no sufficient research data are available on the cardiovascular effect of <i>A. officinarum</i>. Thus, in this study, we investigate whether <i>A. officinarum</i> extract has direct effects on vascular reactivity.<h4>Methods</h4>To examine whether <i>A. officinarum</i> extract affects vascular functionality, we measured isometric tension in rat mesenteric resistance arteries using a wire myograph. After arteries were pre-contracted with high-K<sup>+</sup> (70 mM), phenylephrine (5 µM), or U46619 (1 µM), <i>A. officinarum</i> extract was treated.<h4>Results</h4><i>A. officinarum</i> extract induced vasodilation in a concentration-dependent manner, and this effect was endothelium independent. To further investigate the mechanism, we incubated arteries in a Ca<sup>2+</sup>-free and high-K<sup>+</sup> solution, followed by the cumulative addition of CaCl<sub>2</sub> (0.01-2.5 mM) with or without <i>A. officinarum</i> extract (30 µg/mL). Pre-treatment of <i>A. officinarum</i> extract reduced the contractile responses induced by cumulative administration of Ca<sup>2+</sup>, which suggests that extracellular Ca<sup>2+</sup> influx was inhibited by the treatment of <i>A. officinarum</i> extract. These results were associated with a reduction in phosphorylated MLC<sub>20</sub> in VSMCs treated with <i>A. officinarum</i> extract. Furthermore, eucalyptol, an active compound of <i>A. officinarum</i> extract, had a similar effect as <i>A. officinarum</i> extract, which causes vasodilation in mesenteric resistance arteries.<h4>Conclusion</h4><i>A. officinarum</i> extract and its active compound eucalyptol induce concentration-dependent vasodilation in mesenteric resistance arteries. These results suggest that administration of <i>A. officinarum</i> extract could exert beneficial effects to treat high blood pressure."],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Vasodilatory Effect of <i>Alpinia officinarum</i> Extract in Rat Mesenteric Arteries."],"pmcid":["PMC9104054"],"funding_grant_id":["2020"],"pubmed_authors":["Haam CE","Lim S","Byeon S","Choi SK","Choi SJ","Lee YH"],"additional_accession":[]},"is_claimable":false,"name":"Vasodilatory Effect of <i>Alpinia officinarum</i> Extract in Rat Mesenteric Arteries.","description":"<h4>Background</h4><i>Alpinia officinarum</i> (<i>A. officinarum</i>) is known to exhibit a beneficial effect for anti-inflammatory, anti-oxidant, and anti-hyperlipidemic effects. However, no sufficient research data are available on the cardiovascular effect of <i>A. officinarum</i>. Thus, in this study, we investigate whether <i>A. officinarum</i> extract has direct effects on vascular reactivity.<h4>Methods</h4>To examine whether <i>A. officinarum</i> extract affects vascular functionality, we measured isometric tension in rat mesenteric resistance arteries using a wire myograph. After arteries were pre-contracted with high-K<sup>+</sup> (70 mM), phenylephrine (5 µM), or U46619 (1 µM), <i>A. officinarum</i> extract was treated.<h4>Results</h4><i>A. officinarum</i> extract induced vasodilation in a concentration-dependent manner, and this effect was endothelium independent. To further investigate the mechanism, we incubated arteries in a Ca<sup>2+</sup>-free and high-K<sup>+</sup> solution, followed by the cumulative addition of CaCl<sub>2</sub> (0.01-2.5 mM) with or without <i>A. officinarum</i> extract (30 µg/mL). Pre-treatment of <i>A. officinarum</i> extract reduced the contractile responses induced by cumulative administration of Ca<sup>2+</sup>, which suggests that extracellular Ca<sup>2+</sup> influx was inhibited by the treatment of <i>A. officinarum</i> extract. These results were associated with a reduction in phosphorylated MLC<sub>20</sub> in VSMCs treated with <i>A. officinarum</i> extract. Furthermore, eucalyptol, an active compound of <i>A. officinarum</i> extract, had a similar effect as <i>A. officinarum</i> extract, which causes vasodilation in mesenteric resistance arteries.<h4>Conclusion</h4><i>A. officinarum</i> extract and its active compound eucalyptol induce concentration-dependent vasodilation in mesenteric resistance arteries. These results suggest that administration of <i>A. officinarum</i> extract could exert beneficial effects to treat high blood pressure.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-19T16:20:14.424Z","creation":"2025-04-19T16:20:14.424Z"},"accession":"S-EPMC9104054","cross_references":{"pubmed":["35566064"],"doi":["10.3390/molecules27092711"]}}