{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang S"],"funding":["The National Natural Science Foundation of China/Research Grants Council Joint Research Scheme","Shenzhen Knowledge Innovation Programme of the Shenzhen Science and Technology Innovation Commission","The Hong Kong University Shenzhen Hospital Scientific Research Training Plan"],"pagination":["4613"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9104239"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(9)"],"pubmed_abstract":["Human endometrium is an incredibly dynamic tissue undergoing cyclic regeneration and shedding during a woman's reproductive life. Endometrial mesenchymal stromal/stem-like cells (eMSC) contribute to this process. A hypoxic niche with low oxygen levels has been reported in multiple somatic stem cell types. However, the knowledge of hypoxia on eMSC remains limited. In mice, stromal stem/progenitor cells can be identified by the label-retaining technique. We examined the relationship between the label-retaining stromal cells (LRSC) and hypoxia during tissue breakdown in a mouse model of simulated menses. Our results demonstrated that LRSC resided in a hypoxic microenvironment during endometrial breakdown and early repair. Immunofluorescence staining revealed that the hypoxic-located LRSC unde"],"journal":["International journal of molecular sciences"],"pubmed_title":["Hypoxia Regulates the Self-Renewal of Endometrial Mesenchymal Stromal/Stem-like Cells via Notch Signaling."],"pmcid":["PMC9104239"],"funding_grant_id":["HKUSZH20192003","JCYJ20180508153031952","N_HKU 732/20"],"pubmed_authors":["Yeung WSB","Chan RWS","Ng EHY","Zhang S"],"additional_accession":[]},"is_claimable":false,"name":"Hypoxia Regulates the Self-Renewal of Endometrial Mesenchymal Stromal/Stem-like Cells via Notch Signaling.","description":"Human endometrium is an incredibly dynamic tissue undergoing cyclic regeneration and shedding during a woman's reproductive life. Endometrial mesenchymal stromal/stem-like cells (eMSC) contribute to this process. A hypoxic niche with low oxygen levels has been reported in multiple somatic stem cell types. However, the knowledge of hypoxia on eMSC remains limited. In mice, stromal stem/progenitor cells can be identified by the label-retaining technique. We examined the relationship between the label-retaining stromal cells (LRSC) and hypoxia during tissue breakdown in a mouse model of simulated menses. Our results demonstrated that LRSC resided in a hypoxic microenvironment during endometrial breakdown and early repair. Immunofluorescence staining revealed that the hypoxic-located LRSC unde","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-04T20:35:59.909Z","creation":"2025-04-04T20:35:59.909Z"},"accession":"S-EPMC9104239","cross_references":{"pubmed":["35563003"],"doi":["10.3390/ijms23094613"]}}